Depression and Anxiety Trial, Recruiting

Written by an AI model from the ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People aged 18 to 70 years old.
• People who have been diagnosed with a major depressive episode, confirmed through a structured clinical interview, with a depression rating score of 18 or higher on a standard scale.
• People who continue to have thoughts of suicide beyond the initial screening period, confirmed by a score of 4 or higher on a standard assessment tool.
• People who pass both a safety screening questionnaire for TMS (a type of brain stimulation) and a safety screening questionnaire for MRI.
• People whose current episode of depression has not responded adequately to at least two antidepressant medications at proper doses, or who were unable to tolerate at least two antidepressant medications, or a combination of one that did not work and one that was not tolerated — as measured by a standardised treatment history form.
• People whose psychiatric symptoms have been confirmed as not caused by an underlying physical medical condition.
• People who are voluntary outpatients, able to give informed consent, and are being seen at the UC San Diego Health Interventional Psychiatry program.
• People who are able to attend and follow the required treatment schedule.

Who may not be able to join:

• People who have been diagnosed with a substance use disorder within the last 3 months.
• People who have ever been diagnosed with bipolar I or II disorder, schizophrenia, schizoaffective disorder, schizophreniform disorder, or delusional disorder, or who are currently experiencing psychotic symptoms.
• People who have obsessive compulsive disorder, post-traumatic stress disorder (current or within the last year), an anxiety disorder, or dysthymia, where a study investigator determines that condition is the primary problem causing more impairment than the depression.
• People who have a personality disorder that a study investigator determines is the primary problem causing more impairment than the depression.
• People whose thoughts of suicide have led to an emergency involuntary hospital admission.
• People who are currently pregnant or breastfeeding, or people of childbearing potential who are not using adequate contraception.
• People who have an uncorrectable significant sensory impairment that would prevent them from participating in interviews (for example, a significant hearing difficulty).
• People who are not able to give informed consent or are not suitable for outpatient treatment.
• People who have a serious unstable medical illness, a cardiac pacemaker, or an implanted medication pump; or who have a significant neurological condition such as a history of seizures (other than those caused by ECT treatment or a childhood febrile seizure), a brain tumour, cerebral aneurysm, Parkinson's disease, Huntington's disease, multiple sclerosis, or a head injury involving more than 5 minutes of unconsciousness; or who have any metal implants in or near the head, such as aneurysm clips, stimulators, cochlear implants, or electrodes, that cannot be safely removed.
• People who are currently taking more than the equivalent of 2 mg of lorazepam per day, or any dose of an anti-seizure medication, as these may reduce the effectiveness of the treatment being studied.

Important: Always verify eligibility with the trial site directly before applying.