Phase 2 Pancreatic Cancer Trial, Recruiting NCT05379985 Sponsor: Revolution Medicines, Inc. Condition: Pancreatic Cancer
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Phase 2 Pancreatic Cancer Trial, Recruiting

NCT05379985
Recruiting Phase 2

Who may be able to join

AI generated eligibility summary. Written by an AI model from the official source data and checked on a sample basis. It can contain mistakes, so confirm anything important against the original source. How we use AI

Who might be able to join this trial:

  • Your cancer must be an advanced solid tumor that has been confirmed by a lab test (biopsy), with a specific genetic change (mutation) in a gene called KRAS G12 or RAS, found through DNA testing — or, for one part of the trial, a pancreatic cancer without a RAS mutation
  • You may be either new to treatment or have already received the standard treatments available for your type and stage of cancer
  • You must be well enough to carry out daily activities with little to no limitation (confirm with trial site for exact definition)
  • Your liver, kidneys, and other organs must be working well enough to safely participate

Who may not be able to join:

  • People whose cancer started in the brain or spinal cord are not eligible
  • People who have cancer that has spread to the brain and is currently not being treated are not eligible
  • People who have difficulty swallowing or absorbing oral (by mouth) medication due to a digestive system problem are not eligible
  • People who have another serious or unstable health condition that, in the doctor's opinion, could put them at risk, affect how long they are expected to live during the study, or make it hard for them to follow the study requirements are not eligible

Important: Always verify eligibility with the trial site directly before applying.

Note: Other eligibility requirements not listed here may also apply — the trial team will review your full medical history.

Based on publicly available eligibility criteria from ClinicalTrials.gov. Verify directly with the trial site before acting. This is not medical advice.

This is a simplified plain English summary of the eligibility criteria. Full criteria are set by the trial investigators and may include additional requirements not shown here. Never self-exclude from a trial based on this summary. Contact the trial site directly to confirm your eligibility.
Last synced 22 July 2026
Phase 2: approximately ~30% of drugs entering this phase reach regulatory approval, based on published industry-wide historical data. This is not specific to this trial.
Phase success rates shown are historical industry-wide averages based on published data. They are not a prediction for this specific trial or your individual situation.

Contact this trial

Principal Investigator: Revolution Medicines, Inc., Revolution Medicines, Inc.

Phone: 1-844-273-8633

Contact details sourced from ClinicalTrials.gov. Verify directly with the trial site before attending.

GP referral letter

Print a one-page summary to share with your doctor.

Trial details

Status
Recruiting
Phase
Phase 2
Sponsor
Revolution Medicines, Inc.
Registry
ClinicalTrials.gov
Start date
31 May 2022
Est. completion
31 May 2027

Where this trial is recruiting

🇺🇸 United States

Primary endpoints

Incidence and severity of treatment-emergent Adverse Events (AEs) and serious AEs, including incidence and severity of findings in laboratory values and vital signs; Number of Participants with Dose-Limiting Toxicity (DLT)

Can't join this trial?

Expanded access pathways

If this trial is not available to you, other access pathways may exist. In Australia, the TGA Special Access Scheme allows access to unapproved therapeutic goods for individual patients.

TGA Special Access Scheme information

Find other recruiting trials on ClinicalTrials.gov

Data last synced from ClinicalTrials.gov: 22 July 2026. Trial status can change. Always verify current status directly with the trial site before making any decision.

Trial recruitment status can change without notice between our nightly data updates. Always contact the trial site directly to confirm current recruitment status before making any decisions or travel arrangements.

View original record on ClinicalTrials.gov