Depression and Anxiety Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People aged 18 to 55 years old at the time of signing consent forms.
• Current or former US military service members whose care is provided at a Military Treatment Facility or Veterans Administration Medical Center.
• People who are able to provide written informed consent in English.
• People with a self-reported or medically diagnosed history of concussion (also called mild traumatic brain injury) that occurred more than 6 months ago but less than 26 years ago, involving a brief loss of consciousness, altered awareness, or short-term memory loss around the time of the injury.
• People whose depression screening score indicates at least mild-to-moderate depressive symptoms at the time of screening.
• People who have been on a stable psychiatric medication plan for at least six weeks and a stable behavioral therapy plan for at least twelve weeks before joining the study.
• Female participants of childbearing potential who agree to use an effective form of birth control for the duration of the study.
• People who are currently under the care of a primary care doctor and/or a mental health provider.

Who may not be able to join:

• People with a history of unprovoked seizures, a seizure within 24 hours of a head injury, or two or more close family members (parent, sibling, or child) with a history of unprovoked seizures.
• People with a history of moderate, severe, or penetrating traumatic brain injury (more serious than a concussion).
• People with a growth, bleed, or other abnormality inside the skull that, in the opinion of the research team, could increase seizure risk or interfere with brain scan quality.
• People currently taking medications or substances that, in the opinion of the research team, lower the threshold for seizures (such as certain antidepressants or antipsychotic medications).
• People who are unable to safely have a 3T MRI scan without sedation or contrast dye, based on the radiology department's assessment at the trial site.
• People with severe claustrophobia that would prevent them from completing a closed-bore MRI scan without medication or sedation.
• People with a history of severe or recently uncontrolled heart disease.
• People with a cardiac pacemaker or lines running into the heart.
• People with any implanted device, prosthesis, or permanent body alteration that, in the opinion of the research team, would be unsafe during MRI or brain stimulation, or would interfere with scan quality.
• People with rapidly progressing illnesses such as late-stage cancer, a neurodegenerative condition, or major organ failure.
• People with a history of Bipolar Disorder or Schizophrenia Spectrum Disorders.
• People currently showing signs of psychosis, mood problems caused by substance use, or depression linked to a medical condition other than a brain injury.
• People with severe or uncontrolled substance use.
• People who have previously received open-label TMS (transcranial magnetic stimulation) treatment at any point in their life.
• People who have received other types of brain stimulation treatments — including tDCS, tACS, Alpha-Stim, or electroconvulsive therapy — within the 12 weeks before joining the study.
• People who have made a suicide attempt within the six months before enrollment.
• People with amputation of the right arm or another condition that would prevent calibration of the brain stimulation treatment on the left side of the brain.
• People who would be unable to complete the full study timeline, for example due to a planned hospitalisation during the study period.
• People whose freedom of movement is legally restricted, including those who are incarcerated.
• People who, in the opinion of the research team, may have safety concerns, reliability concerns, or other factors that could affect the scientific quality of the study data.

Important: Always verify eligibility with the trial site directly before applying.