Depression and Anxiety Trial, Recruiting NCT05464888 Sponsor: University of North Carolina, Chapel Hill Condition: Depression and Anxiety
Back to Depression And Anxiety

Depression and Anxiety Trial, Recruiting

NCT05464888
Recruiting Not Applicable

Who may be able to join

AI generated eligibility summary. Written by an AI model from the official source data and checked on a sample basis. It can contain mistakes, so confirm anything important against the original source. How we use AI

Who might be able to join this trial:

  • Children who are between 4 and 8 years of age
  • Children who speak English
  • Children who have not had a dental cleaning or oral exam in the past 3 months, making them due for one
  • Children who are in stable general health, as determined by the study coordinator and lead researcher
  • Children who are able to understand and follow what the study involves, including being available on the required visit dates, based on the assessment of the research team
  • Children whose parent or legal guardian has signed and dated a consent form, and where the child has also given their own agreement (assent) to take part, after all aspects of the trial have been explained and all questions answered

Who may not be able to join:

  • Children younger than 4 or older than 8 years of age
  • Children who do not speak English
  • Children who are unwilling to participate, or whose parent or legal guardian has not given consent
  • Children who are currently experiencing dental pain, based on their own or their parent's report
  • Children with known allergies or significant reactions to dogs, toothpaste, mouth rinse, or any ingredient in dental cleaning paste
  • Children who are afraid of dogs, or who have had a previous negative experience with dogs, as reported by the child or parent
  • Children with a serious medical or psychiatric condition that the lead researcher considers could increase risk or affect the study results
  • Children with a developmental or cognitive disability that means they are unable to understand, agree to, or follow the requirements of the study, based on the research team's assessment

Important: Always verify eligibility with the trial site directly before applying.

Based on publicly available eligibility criteria from ClinicalTrials.gov. Verify directly with the trial site before acting. This is not medical advice.

This is a simplified plain English summary of the eligibility criteria. Full criteria are set by the trial investigators and may include additional requirements not shown here. Never self-exclude from a trial based on this summary. Contact the trial site directly to confirm your eligibility.
Last synced 26 July 2026
This study is not part of the standard drug-approval phase pathway (for example an observational, device, behavioural, or registry study), so a phase success rate does not apply.

Contact this trial

Principal Investigator: Laura A Jacox, DMD, PhD, MS, University of North Carolina, Chapel Hill

Phone: 919-537-3424

Contact details sourced from ClinicalTrials.gov. Verify directly with the trial site before attending.

GP referral letter

Print a one-page summary to share with your doctor.

Trial details

Status
Recruiting
Phase
Not Applicable
Registry
ClinicalTrials.gov
Start date
2 February 2023
Est. completion
1 February 2028

Where this trial is recruiting

🇺🇸 United States

Primary endpoints

Mean Heart Rate during Dental Exam; Mean Heart Rate during Dental Cleaning; Mean Heart Rate during Dental Radiograph Simulation; Salivary Cortisol during Dental Exam; Salivary Cortisol during Dental Cleaning; Salivary Cortisol during Dental Radiograph Simulation; Salivary Amylase during Dental Exam; Salivary Amylase during Dental Cleaning; Salivary Amylase during Dental Radiograph Simulation

Can't join this trial?

Expanded access pathways

If this trial is not available to you, other access pathways may exist. In Australia, the TGA Special Access Scheme allows access to unapproved therapeutic goods for individual patients.

TGA Special Access Scheme information

Find other recruiting trials on ClinicalTrials.gov

Data last synced from ClinicalTrials.gov: 26 July 2026. Trial status can change. Always verify current status directly with the trial site before making any decision.

Trial recruitment status can change without notice between our nightly data updates. Always contact the trial site directly to confirm current recruitment status before making any decisions or travel arrangements.

View original record on ClinicalTrials.gov