Pancreatic Cancer Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• You are willing and able to sign a consent form before any trial-related procedures begin.
• You are willing and able to follow the trial schedule, including all visits, treatments, and check-ups.
• Your pancreatic cancer has been confirmed by a lab test (biopsy or cell sample).
• Your cancer has spread to other parts of the body (metastatic).
• Your cancer can be measured or assessed using medical scans.
• You have not yet received any chemotherapy as your main treatment for pancreatic cancer (previous chemotherapy given before or after surgery for early-stage disease is not allowed).
• You are 18 years of age or older (patients aged 75 or older must pass a specific health assessment called the G8 screening tool with a score of 14 or above).
• You are generally able to carry out daily activities with no or minimal limitations (confirm with trial site).
• A tissue sample from your pancreatic tumour or a liver metastasis (that has not been treated with chemotherapy) is available before joining the trial.
• Your blood test results from within the past 7 days show that your liver, kidneys, and blood cells are working well enough to meet specific levels set by the trial (confirm exact values with trial site).
• You do not have a genetic enzyme deficiency called DPD deficiency, checked through a uracil level blood test.
• Your life expectancy is at least 3 months.
• If you are a woman who could become pregnant, you must either be post-menopausal or have a negative pregnancy test.
• You are registered with a national healthcare system.

Who may not be able to join:

• You are currently taking part in another clinical trial that involves a treatment intervention.
• You have previously received chemotherapy for pancreatic cancer.
• You have large, uncontrolled build-ups of fluid around your lungs or in your abdomen.
• You have a specific inherited enzyme variation called UGT1A1*28 (homozygous), which affects how your body processes certain drugs (confirm with trial site).
• You have an active serious infection such as tuberculosis, hepatitis B, hepatitis C, COVID-19, or HIV that requires treatment.
• You have been diagnosed with another cancer in the past 3 years (except for certain treated skin cancers or early-stage cervical changes).
• You have active cancer that has spread to the brain or the lining of the brain; however, previously treated and stable brain metastases may be considered (confirm with trial site).
• You have other serious uncontrolled health conditions, such as severe heart disease, severe lung disease, advanced liver disease, serious bowel conditions causing diarrhoea, or significant mental health conditions that could affect your ability to take part safely.
• You have received a live vaccine within 30 days before starting the trial treatment.
• You have a known allergy or sensitivity to any of the drugs used in this trial.
• You have any other condition, treatment, or test result that the trial doctor believes would make participation unsafe or affect the trial results.
• You have had radiotherapy covering a large area of your bone marrow or a wide area of your body within the past 4 weeks.
• You have had a major surgical procedure within the past 4 weeks.
• You are pregnant or breastfeeding.
• You are under legal guardianship or a legal protection order (confirm with trial site).

Important: Always verify eligibility with the trial site directly before applying.