Depression and Anxiety Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

For people with opioid use:

• People aged 18 to 60 years old, male or female
• People who are already taking part in a related study called H-22611
• People whose responses to a substance use screening questionnaire (WHO-ASSIST) indicate opioid use at a score of 4 or above
• People whose responses to a depression questionnaire (PHQ-9) indicate depressive symptoms
• People whose responses to a suicide-related questionnaire (SBQ-R) indicate active suicidal thoughts
• People who are able to understand, agree to, and sign a consent form, and are willing to complete all study steps
• Female participants who are not pregnant and not breastfeeding at the time of brain scan and treatment sessions
• People with no medical or physical reasons that would make MRI scanning unsafe (such as a pacemaker, cochlear implants, or metal in the eyes or body), and who pass the pre-screening questions from the brain imaging centre
• People with no medical or physical reasons that would make brain stimulation treatment (TMS) unsafe (such as non-removable metal in the head, excluding the mouth, or within 12 inches of the treatment device)

For healthy volunteers (comparison group):

• People aged 18 to 60 years old, male or female
• People with no history of serious medical or neurological conditions
• People who are able to understand, agree to, and sign a consent form, and are willing to complete all study steps
• Female participants who are not pregnant and not breastfeeding at the time of brain scan sessions
• People with no medical or physical reasons that would make MRI scanning unsafe, and who pass the pre-screening questions from the brain imaging centre
• People with no medical or physical reasons that would make brain stimulation (TMS) unsafe

Who may not be able to join:

• People who the clinical and research team believe are unlikely to complete the study, including those who may not be able to tolerate the brain stimulation treatment
• People who are unable to understand how the study works or what it involves
• People who are unable to sign a consent form for any reason
• People with an unstable or serious medical condition, including HIV/AIDS, active hepatitis, active tuberculosis, unstable heart disease, unstable diabetes, or liver or kidney problems
• Female participants who are pregnant or breastfeeding
• People who have medical or physical reasons that make MRI scanning unsafe, or who do not pass the brain imaging centre's pre-screening questions
• People who have medical or physical reasons that make brain stimulation (TMS) unsafe, including non-removable metal in the head (excluding the mouth) or within 12 inches of the treatment device
• People who do not speak English (confirm with trial site for any updates on language support)

Important: Always verify eligibility with the trial site directly before applying.