Parkinson's Disease Trial, Recruiting

Written by an AI model from the ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• You must be able to understand what the study involves and be willing to sign a consent form agreeing to take part.
• You must be willing and able to attend all scheduled visits and complete all required study procedures and tests.
• You must be able to travel to the research site for study procedures.
• You must be 25 years old or older.
• If you are a woman, you must either be unable to become pregnant (due to surgery or natural menopause lasting at least 12 months), or if you could become pregnant, you must not currently be pregnant (confirmed by a urine test) and must not be breastfeeding.
• All participants must use a highly effective form of birth control throughout the study (such as hormonal contraception, an IUD, tubal ligation, a vasectomised partner, or abstinence).
• If you are a sexually active man, you must agree to use condoms and ensure effective contraception is used during the study and for 3 months after your last scan, to prevent pregnancy in a partner.
• You must have adequate vision and hearing to complete the psychological tests, as judged by the study doctor.
• You must not be taking any medications known to interact with a specific brain receptor being studied (confirm with trial site for the full list of medications).
• If you take certain medications that could affect brain imaging results, you must be willing and able to safely stop taking them for a required period before your scan (confirm with trial site).

Who may not be able to join:

• You may not be eligible if the study doctor believes you are unable to make informed decisions for yourself.
• You may not be eligible if you have been diagnosed with dementia.
• You may not be eligible if you currently have or recently had a problem with drug or alcohol misuse.
• You may not be eligible if you are currently taking blood-thinning medications (such as warfarin or heparin), which could make certain procedures unsafe.
• You may not be eligible if you have a condition that makes it unsafe to have a lumbar puncture (spinal tap), such as serious spinal disease or a blood clotting problem.
• You may not be eligible if a circulation test in both hands (called the Allen test) gives a negative result (confirm with trial site).
• You may not be eligible if you have taken certain medications that could affect brain imaging within the past 5 months (confirm with trial site for the full list).
• You may not be eligible if you are currently taking any medications known to affect the specific brain receptor being studied in this trial (confirm with trial site for the full list).
• You may not be eligible if you have taken part in another clinical trial using an experimental drug or device within the last 60 days.
• You may not be eligible if you have had cancer in the last 5 years, with the exception of a non-spreading type of skin cancer (basal cell carcinoma).
• You may not be eligible if you cannot have an MRI scan, for example because you have a pacemaker, metal implants, or metal fragments in your body or eyes.
• You may not be eligible if you are claustrophobic or have back pain that would make lying still in a scanner for extended periods too difficult.
• You may not be eligible if a previous MRI scan showed a significant brain or neurological condition, in the opinion of the study doctor.
• You may not be eligible if you have any significant ongoing medical condition that the study doctor believes could be unstable, could get worse during the study, or could put you at risk.
• You may not be eligible if you have a history of suicidal behaviour or are currently having thoughts of suicide.
• You may not be eligible if you are pregnant, breastfeeding, or plan to become pregnant within the next 18 months.

Important: Always verify eligibility with the trial site directly before applying.