Parkinson's Disease Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People who are able to understand what the study involves and are willing to sign a consent form agreeing to take part.
• People who are able to attend all scheduled visits and follow the study procedures and tests as required.
• People who are able to travel to the research site for study-related procedures.
• Women who are either unable to become pregnant (due to surgery or having gone through menopause, defined as 12 months without a period), or, if able to become pregnant, must not currently be pregnant (confirmed by a urine test) and must not be breastfeeding.
• All participants must use highly effective contraception during the study (such as hormonal contraceptives, an IUD, tubal occlusion, a vasectomised partner, or abstinence).
• Male participants who are sexually active must agree to use condoms during the study and for 3 months after the last imaging scan, and must ensure that a medically approved contraceptive method is also being used by their partner.
• People who have adequate vision and hearing to complete the psychological tests, as judged by the study doctor.
• People who are not taking any medications known to affect the serotonin system (such as antidepressants like SSRIs, tricyclics, or migraine treatments called triptans).
• People who take certain medications that may affect brain imaging scans and who are able, from a medical standpoint, to stop taking them for a required period before the scan (confirm with trial site).

Who may not be able to join:

• People who are not able to make decisions for themselves, as judged by the study doctor.
• People who have been diagnosed with dementia.
• People currently taking blood-thinning medications (such as warfarin or heparin) that could make a lumbar puncture (spinal fluid sample) unsafe.
• People who have a condition that makes a lumbar puncture unsafe, such as severe spine disease, bleeding disorders, or low platelet levels.
• People who have taken certain medications that interfere with brain imaging scans (such as antipsychotics, metoclopramide, or stimulant medications) within 5 months before the screening visit.
• People who have taken an experimental drug or used an experimental device within 60 days before the start of the study (note: dietary supplements such as coenzyme Q10 taken outside a clinical trial are not excluded).
• People with a history of cancer in the last 5 years, except for a certain type of non-spreading skin cancer (basal cell carcinoma).
• People with a current or recent history of drug or alcohol misuse or dependence.
• People who cannot have an MRI scan, such as those with metal implants or devices in their body (for example, a pacemaker, stents, or metal fragments in the eyes).
• People with claustrophobia (fear of enclosed spaces) or back pain that would make lying still in a PET or MRI scanner unbearable.
• People whose previous MRI scan showed signs of a significant neurological condition, in the opinion of the study doctor.
• People with any other medical or psychiatric condition, or abnormal lab results, that the study doctor believes would make participation unsafe or unsuitable.

Important: Always verify eligibility with the trial site directly before applying.