Depression and Anxiety Trial, Recruiting NCT05553353 Sponsor: VA Office of Research and Development Condition: Depression and Anxiety
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Depression and Anxiety Trial, Recruiting

NCT05553353
Recruiting Not Applicable

Who may be able to join

AI generated eligibility summary. Written by an AI model from the official source data and checked on a sample basis. It can contain mistakes, so confirm anything important against the original source. How we use AI

Who might be able to join this trial:

  • You have a spinal cord injury in the neck or upper back area that happened at least 6 months ago (at any level of severity)
  • You are between 18 and 60 years old
  • You have been diagnosed with major depression, confirmed through a structured interview with a clinician
  • Your depression has been rated as moderately severe or above on a standard depression rating scale (confirm with trial site)
  • You are either not taking any antidepressant medications, or your medication doses have not changed for at least 4 weeks before the study (or 6 weeks if you recently started a new medication)

Who may not be able to join:

  • You have another neurological condition or dementia in addition to your spinal cord injury
  • You have significant difficulties with memory or thinking, based on a standard cognitive test
  • You have a history of psychosis or another major psychiatric condition that is considered your primary diagnosis
  • You have screened positive for bipolar disorder on a standard psychiatric interview
  • You have a history of feeling very uncomfortable in enclosed spaces (claustrophobia)
  • Your life expectancy is less than 1 year
  • You have any electronic or metal implants in your body, such as a pacemaker, cochlear implant, or metal in your head
  • You have a history of seizures or are currently taking medication to prevent seizures
  • You are taking any medication that is known to increase the risk of seizures (confirm with trial site)
  • You are pregnant, confirmed by a urine test
  • You have had serious thoughts of suicide recently or have attempted suicide in the past two years (confirm with trial site)
  • You are unable to give informed consent, or you do not wish to give consent to take part

Important: Always verify eligibility with the trial site directly before applying.

Based on publicly available eligibility criteria from ClinicalTrials.gov. Verify directly with the trial site before acting. This is not medical advice.

This is a simplified plain English summary of the eligibility criteria. Full criteria are set by the trial investigators and may include additional requirements not shown here. Never self-exclude from a trial based on this summary. Contact the trial site directly to confirm your eligibility.
Last synced 20 July 2026
This study is not part of the standard drug-approval phase pathway (for example an observational, device, behavioural, or registry study), so a phase success rate does not apply.

Contact this trial

Principal Investigator: Catherine J VanDerwerker, PhD DPT PT, Ralph H. Johnson VA Medical Center, Charleston, SC

Phone: (843) 792-5047

Contact details sourced from ClinicalTrials.gov. Verify directly with the trial site before attending.

GP referral letter

Print a one-page summary to share with your doctor.

Trial details

Status
Recruiting
Phase
Not Applicable
Registry
ClinicalTrials.gov
Start date
31 March 2025
Est. completion
15 April 2027

Where this trial is recruiting

🇺🇸 United States

Primary endpoints

Change from baseline in Hamilton Depression Rating Scale-17 (HAM-D17) score immediately post-intervention

Can't join this trial?

Expanded access pathways

If this trial is not available to you, other access pathways may exist. In Australia, the TGA Special Access Scheme allows access to unapproved therapeutic goods for individual patients.

TGA Special Access Scheme information

Find other recruiting trials on ClinicalTrials.gov

Data last synced from ClinicalTrials.gov: 20 July 2026. Trial status can change. Always verify current status directly with the trial site before making any decision.

Trial recruitment status can change without notice between our nightly data updates. Always contact the trial site directly to confirm current recruitment status before making any decisions or travel arrangements.

View original record on ClinicalTrials.gov