Phase 3 Myeloma Trial, Recruiting

Written by an AI model from the ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• You have been diagnosed with multiple myeloma, confirmed using standard diagnostic guidelines within the past 28 days
• Your myeloma can be measured through blood or urine tests showing certain levels of abnormal proteins (confirm with trial site for specific values)
• You have been scored as either "frail" or "intermediate fit" using a myeloma frailty calculator within the past 28 days
• If scored as "frail," you have low but acceptable blood counts (red blood cells, platelets, and white blood cells) within the past 28 days — blood or platelet transfusions and growth factor support are allowed if your low counts are due to myeloma
• If scored as "intermediate fit," you meet at least one of these: significantly reduced kidney function, low blood counts in certain ranges, or advanced-stage (stage III) myeloma — confirmed by tests within the past 28 days
• If scored as "frail," you have some level of kidney problems but are NOT on dialysis
• You have had a full body imaging scan (preferably a PET/CT scan) within the past 60 days
• Your liver function blood tests are within an acceptable range within the past 28 days
• Your heart is working well enough, as judged by your doctor within the past 14 days (if you have heart problems, they must not be severe)
• If you have diabetes, it must be reasonably well controlled, shown by a recent blood test within the past 14 days
• If you have HIV, you must be on anti-HIV medication and have an undetectable viral load on your most recent test (within the past 6 months)
• If you have had hepatitis B, your virus levels must be undetectable while on treatment within the past 28 days
• If you have had hepatitis C, you must have been successfully treated and cured, or currently have an undetectable viral load if still on treatment within the past 28 days
• Your general health and ability to carry out daily activities is rated at a moderate level or better (confirm with trial site for exact scoring)
• You are willing to have tissue/blood samples stored for research (with your consent)
• You are willing to fill in questionnaires about how you are feeling (available in English or Spanish)
• You have been told this is a research study and have signed a consent form (a legal representative may sign on your behalf if needed)

Who may not be able to join:

• You have already received treatment for multiple myeloma, with limited exceptions: a short emergency course of steroids, up to one cycle of certain chemotherapy (not including daratumumab-based treatment), or completed radiotherapy to a specific area at least 3 days before starting the study treatment
• You have severe nerve damage in your hands or feet (grade 4 peripheral neuropathy)
• Your blood pressure has been too high (above 140/90) at any point in the 14 days before joining, and has not returned to normal
• You have another cancer (past or present) that your doctor believes could interfere with this study's treatment or results
• You are currently pregnant or breastfeeding
• You are able to have children or father children and are not willing to use effective contraception during the study

Important: Always verify eligibility with the trial site directly before applying.