Parkinson's Disease Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People who have been diagnosed with bilateral idiopathic Parkinson's disease (Parkinson's affecting both sides of the body, with no known cause) based on specific medical criteria that include slowness of movement and muscle stiffness or tremor at rest
• People whose Parkinson's disease has been developing for more than 4 years
• People whose symptoms respond well to the medication L-Dopa, with at least a 30% improvement in motor symptoms measured on a standard rating scale (tremor is an exception to this requirement)
• People whose Parkinson's motor symptoms score above a certain level on a standard medical rating scale when not taking medication
• People whose tremor is not well controlled by current medication and makes up the main part of their symptoms, and whose treatment has remained stable
• People who experience major movement fluctuations, including prolonged periods of reduced mobility and/or uncontrolled involuntary movements (dyskinesias)
• People who are considered suitable candidates for a specific type of brain surgery involving electrode implants placed on both sides of the brain in an area called the STN
• People whose disease severity, measured on a standard scale, is at or below a certain level when taking their best medication
• People whose ability to carry out daily activities is affected beyond a certain level, as measured by a standard rating scale
• People who do not have other health conditions that would prevent them from safely undergoing general anaesthesia, brain surgery, or completing the follow-up required by the study

Who may not be able to join:

• People currently experiencing a significant depressive episode, as measured by a standard depression scale (note: past depressive episodes that have fully resolved before joining may not be a barrier — confirm with trial site)
• People who have had or are currently experiencing psychotic episodes such as hallucinations (mild or brief episodes that fully resolved before joining may not be a barrier — confirm with trial site)
• People showing signs of dementia, based on a standard memory and thinking assessment
• People for whom general anaesthesia is not medically safe
• People who cannot have an MRI scan due to having certain implanted devices, such as a pacemaker, cochlear implant, implantable defibrillator, or neurosensory stimulator, or who have certain metal fragments near nerve structures in the eye or brain
• People for whom MRI may carry additional risks, such as those with metal dental braces or other metal prostheses, those who have difficulty staying still, pregnant women, people with certain types of brain shunts, or people with tattoos containing iron particles (confirm with trial site for individual assessment)
• People whose brain MRI shows certain abnormalities, such as stroke damage, abnormal blood vessels, or significant brain shrinkage
• People with serious ongoing illness unrelated to Parkinson's disease
• People for whom surgery is not considered safe
• Women who are pregnant, planning to become pregnant during the study, currently breastfeeding, or who are able to become pregnant and are not using effective contraception
• People who are unable or unwilling to attend regular follow-up appointments for at least 30 months
• People who are currently taking part in another interventional research study
• People who are legally protected or under a form of legal guardianship
• People who are unable to operate the device's remote control and charging system on their own and do not have someone available to assist them
• People who have not provided written consent after being given adequate time to consider participation
• People who are not affiliated with or covered by the French social security system

Important: Always verify eligibility with the trial site directly before applying.