Phase 1 Mesothelioma Trial, Recruiting

Written by an AI model from the ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• You must be 18 years of age or older.
• You must have been diagnosed with advanced cancer, confirmed by a tissue or cell sample test.
• Your cancer must show at least one measurable tumor that can be seen on a scan.
• You must have tried one or more standard cancer treatments that did not work, and no standard treatment options remain (for the early phase of the trial).
• For a later phase of the trial, your tumor tissue must show a certain protein called GP88 when tested; a stored tissue sample can usually be used for this.
• At least 4 weeks must have passed since your last chemotherapy or radiation treatment (6 weeks for certain specific drugs — confirm with trial site).
• You must be well enough to carry out some daily activities (your doctor can assess this using a standard scale).
• Your liver, kidneys, and bone marrow must be working well enough, based on blood tests.
• You must be willing to use highly effective birth control during the trial and for 90 days after it ends (if you or your partner could become pregnant).
• If you are a woman who could become pregnant, you must have a negative pregnancy test before joining.
• Your life expectancy must be greater than 12 weeks.
• If you have triple negative breast cancer, you must have already tried one or more standard treatments for advanced disease (specific requirements apply depending on your tumor type — confirm with trial site).
• If you have hormone-sensitive breast cancer that is no longer responding to hormonal treatment, you must have tried one or more hormonal therapies for advanced disease (confirm with trial site).
• If you have a certain type of lung cancer (non-small cell), you must have tried at least 2 standard treatments, including a platinum-based chemotherapy and an immunotherapy drug (confirm with trial site).
• If you have mesothelioma, you must have received at least one standard treatment, or not be a suitable candidate for standard treatment.
• People of all ethnic backgrounds are welcome to apply.

Who may not be able to join:

• You may not be eligible if you have serious uncontrolled health conditions, such as severe heart problems, a heart attack within the last 6 months, or mental health or personal circumstances that would make it hard to follow the study rules.
• You may not be eligible if your cancer has spread to the brain and is not being controlled or treated (treated and stable brain metastases may be allowed — confirm with trial site).
• You may not be eligible if cancer has spread to the membranes surrounding your brain or spinal cord.
• You may not be eligible if you are currently taking part in another clinical trial or have done so within the last 28 days.
• You may not be eligible if you are pregnant or currently breastfeeding.
• You may not be eligible if you are unable or unwilling to use effective birth control as required by the study.
• You may not be eligible if you have had another type of cancer in the last 2 years (some exceptions may apply for certain minor skin cancers — confirm with trial site).

Important: Always verify eligibility with the trial site directly before applying.