Mesothelioma Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

All groups:

• You must be willing and able to give written consent to take part
• You must agree to attend follow-up appointments every 3 months for the first 2 years, then every 6 months after that
• You must be able to attend follow-up at a participating TRACERx EVO clinic

Group A (early-stage lung cancer):

• You are 18 years old or over and have been diagnosed with early-stage non-small cell lung cancer (NSCLC, stages I to IIIB) and are able to have surgery to remove the tumour
• Your lung cancer has been confirmed by a tissue test, or there is a strong suspicion of cancer on a scan that means surgery is needed
• Your planned surgery follows standard medical guidelines for lung cancer operations
• If you are having surgery without any treatment beforehand, your tumour must be at least 15mm in size so that two separate samples can be taken from it
• If you are receiving treatment before surgery (such as chemotherapy), at least one tissue sample must be available from a biopsy or surgery
• You are considered well enough to have surgery or pre-surgery treatment if needed
• Your general health and ability to carry out daily activities falls within an acceptable range (performance status 0 to 2 — confirm with trial site)

Group B (advanced or spread lung cancer):

• You are 18 years old or over and have been diagnosed with advanced or metastatic non-small cell lung cancer (NSCLC, stage IIIB or above, or stage IV)
• At least one tissue sample is available from your biopsy or surgery
• You are considered well enough to receive cancer treatment
• Your general health and ability to carry out daily activities falls within an acceptable range (performance status 0 to 2 — confirm with trial site)

Group C (small cell lung cancer or pleural mesothelioma):

• You are 18 years old or over and have been diagnosed with small cell lung cancer (SCLC) or pleural mesothelioma (a cancer affecting the lining of the lungs) at any stage
• At least one tissue sample is available from your biopsy or surgery
• You are considered well enough to receive cancer treatment
• Your general health and ability to carry out daily activities falls within an acceptable range (performance status 0 to 2 — confirm with trial site)

Who may not be able to join:

All groups:

• You currently have another type of cancer that is active or being treated (including with hormone therapy)
• You have been diagnosed with or had a recurrence of another cancer within the past 3 years (exceptions include certain skin cancers, early-stage melanoma, and cervical cancer in situ — confirm with trial site)
• You have a psychological condition that would prevent you from giving informed consent
• After surgery or biopsy, it turns out your diagnosis is something other than NSCLC, SCLC, or pleural mesothelioma
• You have a confirmed diagnosis of certain serious infections such as HIV, Hepatitis B, Hepatitis C, syphilis, tuberculosis, or Creutzfeldt-Jakob disease — unless your case is of special scientific interest and has been agreed in advance with the research team (confirm with trial site)
• You have other health conditions that make participation unsafe (confirm with trial site)

Group A only:

• The surgeon was unable to fully remove the tumour, or not enough lymph node samples were taken during surgery
• It is unlikely that two separate tumour samples can be collected (for those not having pre-surgery treatment), based on scans taken before the operation
• After surgery, it is found that your cancer was at a very early, non-invasive stage — you would be withdrawn from the study, though samples already collected would still be used

Groups B and C only:

• There is not enough tissue available from at least one biopsy sample

Important: Always verify eligibility with the trial site directly before applying.