Depression and Anxiety Trial, Recruiting
Who may be able to join
AI generated eligibility summary. Written by an AI model from the official source data and checked on a sample basis. It can contain mistakes, so confirm anything important against the original source. How we use AI
Who might be able to join this trial:
- People aged 18 to 65 years old who are currently admitted to hospital as inpatients
- People who have been diagnosed with severe unipolar (non-bipolar) depression, using specific ICD-10 codes (F32.2, F32.3, F33.2, or F33.3)
- People whose depression scores at least 23 on a standard rating scale called the HAMD17, indicating severe symptoms
- People who are in good general physical health
- People who are able to understand the trial information and are willing to sign a consent form
- People whose drug screening test comes back negative, and, for women, whose urine pregnancy test comes back negative
- People who have been on a stable dose of antidepressant or antipsychotic medication for at least 10 days before entering the trial
- People who have been cleared by an anaesthesiologist (a specialist doctor) as suitable to receive ECT (electroconvulsive therapy)
Who may not be able to join:
- People with a serious physical illness or a serious neurological (brain or nerve) condition
- People who currently have another psychiatric diagnosis alongside their depression, including bipolar depression (as defined by DSM-5 criteria)
- People who currently have, or have ever had, a diagnosis of schizophrenia or schizoaffective disorder
- People who are currently misusing alcohol, recreational drugs, or any medication in a way that suggests ongoing abuse, or who meet the DSM-5 criteria for alcohol or substance dependence
- People who have clinically significant abnormal results on a general physical examination or routine blood tests
- People who are pregnant or breastfeeding
- People for whom a lumbar puncture (spinal tap) would not be safe — for example, due to raised pressure in the brain, blood-thinning medication, a bleeding or clotting disorder, a spine abnormality present from birth, a recent spine injury or surgery, or a skin infection at the puncture site
- People who have any implant or stainless steel surgical graft in their body that would make an MRI scan unsafe
Important: Always verify eligibility with the trial site directly before applying.
Based on publicly available eligibility criteria from ClinicalTrials.gov. Verify directly with the trial site before acting. This is not medical advice.
Contact this trial
Phone: +43 1 40400 35350
Contact details sourced from ClinicalTrials.gov. Verify directly with the trial site before attending.
GP referral letter
Print a one-page summary to share with your doctor.
Trial details
Where this trial is recruiting
Primary endpoints
imaging parameter - sMRI; imaging parameters - DTI; imaging parameters - fMRI; imaging parameters - rsfMRI; imaging parameters - MRS; biochemical parameters - neurodegeneration; biochemical parameters - inflammation; biochemical parameters - neurplasticity; response prediction
Can't join this trial?
Data last synced from ClinicalTrials.gov: 19 July 2026. Trial status can change. Always verify current status directly with the trial site before making any decision.