Phase 3 Depression and Anxiety Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• You are between 18 and 65 years old (inclusive)
• You are able and willing to give your consent to take part and can take medication by mouth
• You are in generally good physical health
• You have been diagnosed with Major Depressive Disorder (clinical depression) confirmed by a standard psychiatric interview
• Your current episode of depression has not improved enough with your current antidepressant, or you have had a relapse of depression while taking it
• You are tolerating your current antidepressant well and do not plan to change your treatment during the study
• You have been on your current antidepressant at a stable dose for at least 4 weeks (or 6 weeks if you take fluoxetine) before the study starts
• If you are a woman who could become pregnant, you are willing to use reliable contraception and take a pregnancy test at the start of the study

Who may not be able to join:

• You have a primary diagnosis of bipolar disorder, a psychotic disorder, obsessive-compulsive disorder, an eating disorder, PTSD, or an alcohol or substance use disorder within the past 4 weeks (excluding nicotine or caffeine use)
• You have taken drugs that suppress or stimulate the immune system (such as steroids or methotrexate) within the past 21 days
• You have a history of stomach ulcers or gastrointestinal (gut) bleeding
• You currently have an active infection or inflammatory bowel condition
• You have serious heart disease, heart failure, or unstable coronary artery disease (including recent bypass surgery)
• You have significant liver problems (confirm with trial site for specific test values)
• You have significant kidney problems (confirm with trial site for specific test values)
• You have taken tetracycline antibiotics or anti-inflammatory painkillers (such as ibuprofen) for more than 14 days in the past 2 months, or you have a known sensitivity or intolerance to these types of drugs
• You have chronically high blood pressure with a systolic reading above 170 mmHg
• You have tested positive for Hepatitis B, Hepatitis C, or HIV
• You have had electroconvulsive therapy (ECT) within the past 2 months
• You have donated blood in the 30 days before the study starts
• You are currently pregnant or breastfeeding
• You are currently taking part in another intervention study

Important: Always verify eligibility with the trial site directly before applying.