Phase 1 Myeloma Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• You must be 18 years of age or older
• You must be relatively healthy and active in daily life, with only minor limitations from your condition (confirm with trial site for what this means in your case)
• You must have been diagnosed with multiple myeloma according to standard international guidelines
• You must have received between 1 and 3 previous treatment regimens for multiple myeloma, including specific drug types: a proteasome inhibitor, an immunomodulatory drug, and an anti-CD38 antibody (confirm with trial site which drugs count); for certain groups in the trial, at least 2 prior treatment regimens are required
• Your multiple myeloma must currently be getting worse (progressing), and you must have a specific genetic change called t(4;14), confirmed by a specialised lab test on a fresh tissue sample
• Your myeloma must be measurable through at least one of several specific blood, urine, or bone marrow tests (confirm with trial site which applies to you)
• If joining a specific group using the drug pomalidomide, you must agree to enrol in a special safety monitoring programme

Who may not be able to join:

• You recently received certain cancer treatments — for example, chemotherapy, immunotherapy, or radiation within the last 2 weeks; a stem cell therapy within the last 8 weeks; your own stem cell transplant within the last 100 days; or a donor stem cell transplant within the last 6 months (or longer if you still have transplant-related complications)
• You have had major surgery within the last 4 weeks
• Depending on which group you would join, you may not be eligible if your most recent treatment included specific drugs such as carfilzomib, pomalidomide, or mezigdomide (confirm with trial site which applies to you)
• You have certain other blood or plasma cell conditions alongside your myeloma, such as plasma cell leukaemia, POEMS syndrome, myelodysplastic syndrome, or light chain amyloidosis
• You have active cancer affecting the brain or spinal cord (those with previously treated and stable brain/spinal involvement may still be eligible in some groups — confirm with trial site)
• Your bone marrow, kidneys, liver, lungs, or heart are not functioning well enough (confirm with trial site for specific thresholds)
• You currently have an active infection — such as a bacterial, viral, or fungal infection — that is not under control
• You are taking certain medications that affect how the body processes drugs, including acid-reducing agents or strong blockers/activators of specific liver enzymes, within approximately the past week or more (confirm with trial site for exact details)
• You have had another type of cancer (unrelated to myeloma) that required treatment within the past 2 years, or that has not fully gone away (some exceptions may apply — confirm with trial site)

Important: Always verify eligibility with the trial site directly before applying.