Hypertension Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• The person enrolled must be pregnant at the time of joining the trial.
• The pregnancy must be between 23 weeks and 0 days, and 35 weeks and 6 days along at the time of enrollment.
• The pregnant person must have a high blood pressure condition related to pregnancy — either gestational hypertension or preeclampsia — in its milder form (without severe features, as defined by the American College of Obstetricians and Gynecologists).
• There must be no signs of the severe form of preeclampsia at the time of enrollment.
• There must be no medical reason to deliver the baby immediately at the time of enrollment.
• The care plan at enrollment must involve watchful waiting rather than immediate delivery.
• The pregnancy must be a single baby, or twins where each baby has its own placenta (dichorionic twins), confirmed from 14 weeks of pregnancy onward. (Pregnancies where one twin was lost before 14 weeks may still be eligible.)
• The amniotic sac must be unbroken (waters must not have broken).

Who may not be able to join:

• People with severe preeclampsia, which is identified by any of the following: very high blood pressure readings (top number 160 or above, or bottom number 110 or above, on two separate checks at least 4 hours apart); a very low platelet count in the blood; abnormal liver test results or severe persistent pain in the upper right or middle upper belly that does not improve with medication; reduced kidney function based on blood test results; fluid in the lungs; a new headache that does not go away with medication and has no other explanation; or visual disturbances.
• People who had signs of kidney problems before 20 weeks of pregnancy, including elevated kidney-related blood test results, significant protein in the urine, or a urine dipstick reading of 2+ or higher (when not caused by a urinary tract infection).
• People with a more serious, long-standing form of high blood pressure known as Stage 2 chronic hypertension.
• People for whom the blood pressure medications labetalol and nifedipine XL are medically unsuitable, as listed in official FDA prescribing information.
• People who are unwilling or unable to follow the recommended care plan.
• People whose baby is measuring smaller than the 10th percentile for growth, based on an ultrasound done within 3 weeks before enrollment.
• People whose pregnancy has low amniotic fluid levels (deepest pocket of fluid less than 2 cm), based on an ultrasound done within 48 hours before enrollment.
• People whose baby has a known major physical or chromosomal abnormality.

Important: Always verify eligibility with the trial site directly before applying.