Pancreatic Cancer Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People who have been diagnosed with locally advanced pancreatic cancer (a type of cancer that has not spread to distant parts of the body), confirmed by laboratory testing of tissue or cell samples, as defined by National Comprehensive Cancer Network guidelines.
• People whose cancer has spread to nearby lymph nodes, as long as those lymph nodes can be treated with radiation therapy.
• People who are in relatively good general health and able to carry out daily activities, as measured by a standard scale called the ECOG performance status of 0 or 1 (confirm with trial site for exact meaning).
• People who have already received at least 3 months of certain chemotherapy treatments — FOLFIRINOX, modified FOLFIRINOX, and/or gemcitabine/nab-paclitaxel — for their pancreatic cancer, and whose cancer has not spread to distant parts of the body during that time.
• People whose most recent blood test for a cancer marker called CA 19-9 showed a result of 500 U/mL or below.
• People whose blood counts and organ function meet certain minimum levels, including healthy enough levels of red blood cells (which may be achieved through a transfusion), white blood cells, platelets, and liver function markers.
• People of childbearing potential who agree to use an adequate form of contraception throughout the trial, and who agree to inform their treating doctor immediately if they become pregnant or suspect they may be pregnant during the trial.
• People who are able to use a wearable medical device called the NovoTTF-100L system on their own or with the help of another person.
• People who are willing and able to sign a written informed consent form.

Who may not be able to join:

• People whose pancreatic cancer has spread to distant parts of the body (distant metastasis).
• People who are unable to have an MRI scan for any medical reason.
• People who have previously had radiation therapy to the abdomen.
• People who have a history of another cancer, unless: the previous cancer was treated with the intent to cure and has shown no signs of returning for at least 3 years before joining this trial; or it was a certain type of non-aggressive skin cancer with no current signs of disease; or it was a very early-stage cancer (carcinoma in situ) that was adequately treated with no current signs of disease.
• People who still have significant unresolved side effects (above a certain severity level) from previous cancer treatment, unless those side effects are permanent in nature and not expected to be made worse by this trial's treatment.
• People with a history of inflammatory bowel disease, such as Crohn's disease or ulcerative colitis.
• People who have any other condition that, in the opinion of the trial doctor, could interfere with the trial treatment or the ability to assess safety and results.
• People who are currently pregnant or breastfeeding.
• People who have an electrically powered implanted medical device in the torso area, such as a spinal cord stimulator, vagus nerve stimulator, pacemaker, or defibrillator.
• People with a history of significant, uncontrolled heart or cardiovascular disease, including certain types of heart rhythm problems, significant heart disease, poorly controlled high blood pressure, or moderate-to-severe heart failure.
• People with a history of irregular heart rhythms that cause symptoms or require treatment (note: people with atrial fibrillation or flutter that is controlled by medication are not excluded).
• People with a known allergy to medical adhesives or to the conductive gel used in ECG stickers or TENS electrodes.

Important: Always verify eligibility with the trial site directly before applying.