Phase 2 Peripheral Neuropathy Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• You are 18 years of age or older at the time of signing the consent form
• You are reasonably active and able to care for yourself, with only mild limitations on physical activity (confirm with trial site)
• You have been diagnosed with a solid tumor that has spread, cannot be surgically removed, or is locally advanced, confirmed by a tissue or cell sample
• You have already received standard treatments that were available to you
• Your tumor has been tested and shown to have a specific genetic change — a missing gene called MTAP — detected by genetic testing or a lab protein test
• Your liver, kidneys, and other organs are functioning well enough based on recent blood tests
• If you are able to become pregnant, you have a negative pregnancy test at the start of the study
• You are willing and able to sign a written consent form

Who may not be able to join:

• You have a known allergy or serious reaction to the study drugs (TNG462 or pembrolizumab) or their ingredients
• You have another serious illness that is not well controlled and could affect your ability to take part in the study
• You currently have an active infection that requires treatment with medication given into the bloodstream
• You are currently taking part in, or planning to join, another clinical trial testing a different experimental drug or device
• You have a stomach or bowel condition that could affect how your body absorbs the oral study drug
• You have another active cancer at the same time (confirm with trial site)
• You have cancer that has spread to the brain and is causing worsening symptoms
• You currently have an active liver disease of any kind
• You are HIV positive, unless your immune cell count, viral levels, and HIV treatment all meet specific requirements (confirm with trial site)
• You have a significant heart or blood vessel condition (confirm with trial site)
• You are pregnant or currently breastfeeding
• You are unwilling or unable to attend scheduled visits, take the study drug as planned, or follow other study requirements
• In the doctor's opinion, you have another medical condition or history that could affect your safety or the reliability of the study results

Important: Always verify eligibility with the trial site directly before applying.