Colorectal Cancer Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People with a general health status rated as good to moderately functional (ECOG score of 0, 1, or 2)
• People with rectal cancer that has been confirmed through tissue testing (biopsy)
• People whose cancer meets specific staging criteria — either the tumour has grown into surrounding tissue (cT3–cT4), or any tumour size with spread to nearby lymph nodes, with no spread to distant parts of the body
• People whose tumour can be surgically removed, or is expected to be removable after chemoradiotherapy
• People whose treatment plan — chemotherapy followed by chemoradiotherapy before surgery — has been agreed upon at a specialist multidisciplinary team meeting
• People with no cancer spread to distant parts of the body
• Women who could become pregnant must be using adequate contraception
• People who have given free, signed, and informed consent to participate
• Women who could become pregnant must have a negative pregnancy test before joining

Who may not be able to join:

• People with diabetes that is not well controlled
• People who cannot have surgery for any reason
• People who cannot have an MRI scan for any reason
• People who cannot have a PET scan for any reason
• People who cannot receive chemotherapy for any reason
• People who have previously had radiotherapy to the pelvic area
• People with serious existing health conditions that could prevent treatment, or who have an active HIV infection or chronic hepatitis B or C
• People whose rectal cancer is of a specific type called colloid (mucinous) adenocarcinoma
• People whose cancer has already spread to distant parts of the body
• People who cannot tolerate specific chemotherapy drugs: 5-Fluorouracil, oxaliplatin, or irinotecan
• People with a known condition called Gilbert's disease (a liver condition affecting how the body processes certain substances)
• People with a known genetic variation called UGT1A1 (confirm with trial site)
• People with a known deficiency of an enzyme called Glucose-6-Phosphate Dehydrogenase (G6PD)
• People with a history of ongoing diarrhoea or inflammatory disease of the colon or rectum
• People with a history of chest pain (angina) or heart attack
• People with an active or worsening infection, or any other serious medical condition that could interfere with treatment
• People with another current cancer, or a past cancer history — except for certain previously treated skin or cervical cancers (confirm with trial site)
• People already enrolled in another clinical trial testing an experimental treatment
• Women who are pregnant or breastfeeding
• People who are legally unable to give their own consent, or who are under guardianship or have restricted freedom
• People with psychological, family, social, or geographical circumstances that could make it difficult to follow the trial schedule

Important: Always verify eligibility with the trial site directly before applying.