Depression and Anxiety Trial, Recruiting
Who may be able to join
AI generated eligibility summary. Written by an AI model from the official source data and checked on a sample basis. It can contain mistakes, so confirm anything important against the original source. How we use AI
Who might be able to join this trial:
- People aged between 20 and 65 years old
- People who have been diagnosed with major depressive disorder (MDD) or persistent depressive disorder, and who are currently experiencing a moderate-to-severe depressive episode, confirmed by a standard depression rating scale score of 18 or higher
- People with a more severe, long-standing form of depression (called ultra-treatment-resistant depression, or UTRD) who have had depressive symptoms for 5 or more years, have tried more than 6 different antidepressant medications without sufficient benefit, have also tried at least one add-on medication, at least one form of talking therapy, and at least one of the following treatments without sufficient response: esketamine, ketamine given through a drip, electroconvulsive therapy (ECT), or repetitive transcranial magnetic stimulation (rTMS) (confirm with trial site)
- People with a milder form of treatment-resistant depression who have tried at least one antidepressant medication at an appropriate dose for an appropriate length of time without sufficient benefit, and who have never had brain stimulation treatments
Who may not be able to join:
- People for whom MRI scans are not safe or suitable (for example, those with certain metal implants)
- People with other medical or psychiatric conditions that would make participation unsafe, or where depression is not the main psychiatric concern
- People with a history of psychosis
- People who have had problems with substance dependence within the last 6 months
- People with an active neurological condition (a condition affecting the brain or nervous system)
- People with a history of seizures or epilepsy
- People with significant difficulties with memory or thinking (cognitive impairment)
- People who are not able to give their own informed consent to participate
- People who are pregnant
Important: Always verify eligibility with the trial site directly before applying.
Based on publicly available eligibility criteria from ClinicalTrials.gov. Verify directly with the trial site before acting. This is not medical advice.
Contact this trial
Phone: 416-480-6100
Contact details sourced from ClinicalTrials.gov. Verify directly with the trial site before attending.
GP referral letter
Print a one-page summary to share with your doctor.
Trial details
Where this trial is recruiting
Primary endpoints
Change in depressive symptomatology; Imaging
Can't join this trial?
Data last synced from ClinicalTrials.gov: 16 July 2026. Trial status can change. Always verify current status directly with the trial site before making any decision.