Phase 2 Parkinson's Disease Trial, Recruiting

Written by an AI model from the ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• You are between 40 and 85 years old and are generally in good health.
• You are willing and able to give your consent and take part for the full length of the study.
• You completed at least an eighth-grade education, or have a solid work history (confirm with trial site).
• You can see and hear well enough to complete thinking and memory tests (glasses and hearing aids are fine if you use them).
• You speak the local language fluently enough to take part in all assessments.
• You have someone in your life (a partner, family member, or friend) who spends at least 2 hours per week with you and can help with medication and report on how you are doing.
• You have been diagnosed with Parkinson's disease AND are experiencing at least one of the following: seeing things that are not there (hallucinations), sensing a presence that is not there, mistaking one thing for another (illusions), or having strong false beliefs (delusions).
• These symptoms started after your Parkinson's disease diagnosis and have been happening regularly for at least 1 month.
• These symptoms are not better explained by another condition such as schizophrenia or another form of dementia (confirm with trial site).
• You have been experiencing these symptoms at least once a week during the 4 weeks before your screening appointment.
• If you are currently taking medication specifically for these symptoms (hallucinations/delusions), you must have stopped taking it at least 2 weeks before the study begins.
• Your Parkinson's disease medications have stayed the same for at least 4 weeks before the study begins.
• If you take certain memory-support medications, antidepressants, or antipsychotics, they must have been at a stable dose for at least 1 month before screening and are expected to stay the same throughout the study.
• You are willing and able to have repeated MRI brain scans (3 Tesla) with no reasons why an MRI would be unsafe for you.
• You and your partner are both willing to use effective contraception during the study and for 4 days after it ends (hormonal methods for women; condoms for men).

Who may not be able to join:

• You have taken anti-seizure (anticonvulsant) medications within the past month.
• You have taken part in another clinical treatment trial within the past month, or plan to join another trial while this one is ongoing.
• You have previously had a bad reaction to, or could not tolerate, the study drug AGB101 (also known as levetiracetam).
• You have serious kidney problems or are currently on kidney dialysis.
• You are currently experiencing confusion or delirium caused by an infection or other acute medical condition.
• You have another brain or neurological condition besides Parkinson's disease (such as Alzheimer's disease, Huntington's disease, multiple sclerosis, a history of seizures, or significant brain injury with lasting effects) that might interfere with the study.
• You have previously been diagnosed with schizophrenia, bipolar disorder, or another psychotic disorder unrelated to Parkinson's disease.
• You have had deep brain stimulation (DBS) surgery, or have a pacemaker, aneurysm clips, artificial heart valves, ear implants, or any metal fragments or implants in your body that would make an MRI unsafe.
• You have had a problem with alcohol or drug misuse or dependence in the past 3 years.
• You have a serious or unstable physical illness that could make it hard to follow the study's requirements.
• You have an unstable health condition likely to need new medical or surgical treatment during the study that could affect the results.
• You are unable or unwilling to give informed consent or follow the study procedures.
• You or your caregiver are unable to give the daily oral study medication.
• You are currently having thoughts of suicide.
• You are pregnant or breastfeeding (for female participants).
• There is any other reason the study doctor believes you should not take part (confirm with trial site).

Important: Always verify eligibility with the trial site directly before applying.