Colorectal Cancer Trial, Recruiting NCT05838391 Sponsor: Columbia University Condition: Colorectal Cancer
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Colorectal Cancer Trial, Recruiting

NCT05838391
Recruiting Not Applicable

Who may be able to join

AI generated eligibility summary. Written by an AI model from the official source data and checked on a sample basis. It can contain mistakes, so confirm anything important against the original source. How we use AI

Who might be able to join this trial:

  • People who have been diagnosed through a tissue biopsy with a specific type of anal canal cancer (squamous, basaloid, or cloacogenic carcinoma)
  • People whose cancer meets certain size or spread criteria based on medical staging — specifically a tumour larger than 4 cm, or cancer that has spread to nearby lymph nodes (confirm with trial site for exact staging details)
  • People aged 18 or older
  • People who are well enough to carry out basic daily activities, as measured by a standard health performance scale (confirm with trial site)
  • People expected to live longer than 12 months
  • People whose blood, liver, and kidney function results fall within acceptable ranges as determined by the trial site's laboratory tests
  • People who are able and willing to use effective contraception (such as hormonal methods, barrier methods, or abstinence) during the trial and for 6 months after treatment ends, and who agree to report any pregnancies
  • People who are able to understand the trial information and are willing to sign a written consent form

Who may not be able to join:

  • People who have had or currently have another invasive cancer (other than certain common skin cancers), unless they have been cancer-free for 2 or more years
  • People who have previously received chemotherapy or radiation treatment for anal cancer
  • People whose anal cancer has already been completely removed by surgery
  • People whose cancer has come back or spread to distant parts of the body
  • People who have had a known allergic reaction to the chemotherapy drugs 5-Fluorouracil or mitomycin C
  • People who have artificial organ implants, a pacemaker, or other implanted medical devices
  • People who have previously had radiation therapy to the pelvic area in a way that would overlap with the radiation fields planned for this trial
  • People with serious uncontrolled illness, including HIV with a low immune cell count (CD4 below 200) or significant heart disease
  • People who are currently pregnant or breastfeeding

Important: Always verify eligibility with the trial site directly before applying.

Based on publicly available eligibility criteria from ClinicalTrials.gov. Verify directly with the trial site before acting. This is not medical advice.

This is a simplified plain English summary of the eligibility criteria. Full criteria are set by the trial investigators and may include additional requirements not shown here. Never self-exclude from a trial based on this summary. Contact the trial site directly to confirm your eligibility.
Last synced 9 July 2026
This study is not part of the standard drug-approval phase pathway (for example an observational, device, behavioural, or registry study), so a phase success rate does not apply.

Contact this trial

Principal Investigator: Lisa Kachnic, MD, Principal Investigator

Phone: 646-317-4244

Contact details sourced from ClinicalTrials.gov. Verify directly with the trial site before attending.

GP referral letter

Print a one-page summary to share with your doctor.

Trial details

Status
Recruiting
Phase
Not Applicable
Registry
ClinicalTrials.gov
Start date
18 May 2023
Est. completion
31 December 2026

Where this trial is recruiting

🇺🇸 United States

Primary endpoints

Time to plan and deliver treatment fractions.

Can't join this trial?

Expanded access pathways

If this trial is not available to you, other access pathways may exist. In Australia, the TGA Special Access Scheme allows access to unapproved therapeutic goods for individual patients.

TGA Special Access Scheme information

Find other recruiting trials on ClinicalTrials.gov

Data last synced from ClinicalTrials.gov: 9 July 2026. Trial status can change. Always verify current status directly with the trial site before making any decision.

Trial recruitment status can change without notice between our nightly data updates. Always contact the trial site directly to confirm current recruitment status before making any decisions or travel arrangements.

View original record on ClinicalTrials.gov