Phase 2 Myeloma Trial, Recruiting NCT05850234 Sponsor: AstraZeneca Condition: Myeloma
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Phase 2 Myeloma Trial, Recruiting

NCT05850234
Recruiting Phase 2

Who may be able to join

AI generated eligibility summary. Written by an AI model from the official source data and checked on a sample basis. It can contain mistakes, so confirm anything important against the original source. How we use AI

Who might be able to join this trial:

  • You are 18 years of age or older at the time you give your consent to participate
  • You are in generally good physical condition and able to carry out daily activities with little or no limitation (confirm with trial site)
  • You have been formally diagnosed with multiple myeloma (MM) according to recognised medical guidelines
  • You have already received at least 3 previous treatment regimens, which must have included three specific types of therapy: a proteasome inhibitor, an immunomodulatory drug, and an anti-CD38 antibody (confirm with trial site for specific drugs that qualify)
  • Your multiple myeloma has been shown to be getting worse or progressing, based on recognised medical guidelines
  • Your disease can be measured through tests at the start of the study (screening)
  • Your bone marrow, liver, kidneys, and blood counts are functioning well enough, as shown by tests at the start of the study

Who may not be able to join:

  • You have had serious side effects from a previous CAR T-cell therapy or similar T-cell-based treatment
  • You have a history of a non-blood cancer, unless you have been free of that cancer with no signs of it returning for at least 2 years (some exceptions may apply — confirm with trial site)
  • You have significant heart, neurological, or psychiatric conditions
  • You have a serious active or uncontrolled infection
  • You have an active autoimmune disease, or have had one within the past 2 years
  • You have active plasma cell leukaemia at the time of screening
  • You have signs of dementia, confusion, or have had a stroke, brain bleed, or seizure within the 6 months before signing the consent form
  • There is evidence that your multiple myeloma has spread to, or is affecting, your brain or spinal cord

Important: Always verify eligibility with the trial site directly before applying.

Based on publicly available eligibility criteria from ClinicalTrials.gov. Verify directly with the trial site before acting. This is not medical advice.

This is a simplified plain English summary of the eligibility criteria. Full criteria are set by the trial investigators and may include additional requirements not shown here. Never self-exclude from a trial based on this summary. Contact the trial site directly to confirm your eligibility.
Last synced 27 July 2026
Phase 2: approximately ~30% of drugs entering this phase reach regulatory approval, based on published industry-wide historical data. This is not specific to this trial.
Phase success rates shown are historical industry-wide averages based on published data. They are not a prediction for this specific trial or your individual situation.

Contact this trial

Phone: 1-877-240-9479

Contact details sourced from ClinicalTrials.gov. Verify directly with the trial site before attending.

GP referral letter

Print a one-page summary to share with your doctor.

Trial details

Status
Recruiting
Phase
Phase 2
Sponsor
Registry
ClinicalTrials.gov
Start date
20 July 2023
Est. completion
31 August 2027

Where this trial is recruiting

🇺🇸 United States

Primary endpoints

Phase 1b: Adverse Events (AEs); Phase 1b: Dose-Limiting Toxicities (DLTs); Phase 2: Objective Response Rate (ORR)

Can't join this trial?

Expanded access pathways

If this trial is not available to you, other access pathways may exist. In Australia, the TGA Special Access Scheme allows access to unapproved therapeutic goods for individual patients.

TGA Special Access Scheme information

Find other recruiting trials on ClinicalTrials.gov

Data last synced from ClinicalTrials.gov: 27 July 2026. Trial status can change. Always verify current status directly with the trial site before making any decision.

Trial recruitment status can change without notice between our nightly data updates. Always contact the trial site directly to confirm current recruitment status before making any decisions or travel arrangements.

View original record on ClinicalTrials.gov