Depression and Anxiety Trial, Recruiting
Who may be able to join
AI generated eligibility summary. Written by an AI model from the official source data and checked on a sample basis. It can contain mistakes, so confirm anything important against the original source. How we use AI
Who might be able to join this trial:
For people with depression:
- People who have been diagnosed with major depressive disorder (a single episode or recurring episodes) according to standard diagnostic guidelines
- People whose depression symptoms score at least 24 on a standard depression rating scale called the MADRS, indicating moderate to severe depression
- People who need to start a new course of treatment for their depression
- People who have either never taken antidepressant medication for their current episode, or who have stopped long enough that previous medication is no longer affecting their system
- People who have valid health insurance coverage
For healthy volunteers:
- People who have valid health insurance coverage
Who may not be able to join:
For people with depression:
- People whose depression has not responded well to at least two different antidepressant medications taken at the right dose for long enough (known as treatment-resistant depression)
- People who have already tried the medications escitalopram or vortioxetine during their current episode, or for whom either of these medications is medically unsuitable
- People who have a diagnosis of persistent depressive disorder, bipolar disorder, schizophrenia, a neurodevelopmental condition, an active substance use disorder (other than tobacco use), or a severe personality disorder that could make regular follow-up difficult (as judged by the trial doctor)
- People with a history of a neurological condition such as Parkinson's disease or dementia
- People for whom MRI scans are not safe, including those who are pregnant, experience severe claustrophobia, or have certain metal implants in their body
- Women who are pregnant or breastfeeding
- People who are currently hospitalised involuntarily or under a legal protection order
For healthy volunteers:
- People who have a diagnosis of persistent depressive disorder, bipolar disorder, schizophrenia, a neurodevelopmental condition, an active substance use disorder (other than tobacco use), or a severe personality disorder that could make regular follow-up difficult (as judged by the trial doctor)
- People with a history of a neurological condition such as Parkinson's disease or dementia
- People for whom MRI scans are not safe, including those who are pregnant, experience severe claustrophobia, or have certain metal implants in their body
- Women who are pregnant or breastfeeding
Important: Always verify eligibility with the trial site directly before applying.
Based on publicly available eligibility criteria from ClinicalTrials.gov. Verify directly with the trial site before acting. This is not medical advice.
Contact this trial
Phone: 0033683714083
Contact details sourced from ClinicalTrials.gov. Verify directly with the trial site before attending.
GP referral letter
Print a one-page summary to share with your doctor.
Trial details
Where this trial is recruiting
Primary endpoints
Prediction of the therapeutic response (MADRS score) 28 days after the introduction of the antidepressant strategy (V3) based on the early changes (differences between V1 and V2) of the computational phenotype of depressed patients.
Can't join this trial?
Data last synced from ClinicalTrials.gov: 13 July 2026. Trial status can change. Always verify current status directly with the trial site before making any decision.