Hypertension Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People aged 18 to 65 years old
• People with a low level of consciousness, as measured by a standard brain injury scale (Glasgow Coma Scale score of 3 to 8)
• People whose pupils are equal in size and both react to light
• People whose brain CT scan (on arrival or after surgery) shows the brain has shifted no more than 5mm from its normal central position
• People whose brain CT scan shows certain fluid-filled spaces at the base of the brain (called quadrigeminal cisterns) are at least partially open
• People where the first treatment step can be started within 24 hours of the brain injury occurring
• People who meet a specific safety score threshold (called the ELD safety score of 5 or higher) used to assess suitability for the procedure

Who may not be able to join:

• People with a Glasgow Coma Scale score higher than 8 (a less severe level of reduced consciousness)
• People whose brain CT scan shows those fluid-filled spaces at the base of the brain are completely closed off
• People whose brain CT scan shows the brain has shifted more than 5mm from its central position
• People with a Glasgow Coma Scale score of 3 whose pupils are both fixed and dilated (not reacting to light)
• People whose brain CT scan shows signs of severe brain herniation (where parts of the brain are being pushed out of their normal position)
• People with bruising in a specific area of the brain (temporal lobe) where nearby fluid spaces are also closed off on the same side
• People who have suffered a penetrating brain injury (such as a gunshot or stab wound to the head)
• People who have already undergone a surgical procedure to remove part of the skull
• People who are pregnant
• People who are currently incarcerated
• People who, before their injury, already lacked the ability to make their own medical decisions, or who had previously documented wishes to avoid aggressive medical treatment
• People with existing health conditions that already significantly affect their ability to function day-to-day, or whose life expectancy is less than one year
• People for whom the trial procedure cannot safely be performed due to blood clotting problems, use of blood-thinning medications, a very low platelet count (below 50,000), or severe spine deformity
• People with bleeding in the lower back portion of the brain (posterior fossa hemorrhage)

Important: Always verify eligibility with the trial site directly before applying.