Phase 2 Myeloma Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People aged 18 to 75 years old
• People who have been diagnosed with Multiple Myeloma (a type of blood cancer) according to established international guidelines
• People who are newly diagnosed and whose Multiple Myeloma has spread outside the bone marrow to form tumours (called extramedullary disease), including tumours near bones, in soft tissue, or at other sites — confirmed by scan (CT, MRI, or PET-CT) and/or biopsy, with tumours measuring at least 2cm
• People whose blood cell counts and platelet levels meet certain minimum levels set by the trial (confirm with trial site for exact values)
• People whose doctors expect them to live for more than 3 months
• People who do not have an active infection at the time of joining
• Women who could become pregnant must have a negative pregnancy test before starting, and all participants must agree to use two reliable forms of contraception for six months after the last dose of study medication
• People who are willing and able to attend all scheduled visits, follow all treatment plans, and complete all required tests and procedures
• People who have read, understood, and signed a consent form agreeing to take part in the study

Who may not be able to join:

• People who have Hepatitis B, Hepatitis C, or other diseases that affect the immune system (either inherited or acquired, such as HIV/AIDS)
• People who have moderate or severe nerve pain or nerve damage (grade 2 or higher)
• People who have plasma cell leukaemia (a related but different blood cancer)
• People who have had serious blood clotting events
• People with active or unstable heart problems, including chest pain from poor blood flow, uncontrolled heart rhythm problems, significant heart failure, or a heart attack within 3 months before starting the trial
• People with significantly reduced liver function based on blood test results
• People with high levels of bilirubin (a substance measured in blood tests that indicates liver or bile issues)
• People whose kidneys are not filtering blood well enough (below a certain level — confirm with trial site)
• People who have had another active cancer in the past 5 years, except for certain very early-stage skin or cervical cancers
• People who have had major surgery within 30 days before starting the trial
• People who have epilepsy, dementia requiring medication, or other mental health conditions that would make it difficult to follow the study requirements
• People with serious physical or mental health conditions that, in the doctor's opinion, could interfere with the study
• People whose personal, family, social, or geographic circumstances might make it difficult to follow the study schedule
• People who are currently taking part in another clinical trial
• Women who are pregnant or breastfeeding
• People with other health conditions that the trial doctors consider unsuitable for participation (confirm with trial site)

Important: Always verify eligibility with the trial site directly before applying.