Depression and Anxiety Trial, Recruiting
Who may be able to join
AI generated eligibility summary. Written by an AI model from the official source data and checked on a sample basis. It can contain mistakes, so confirm anything important against the original source. How we use AI
Who might be able to join this trial:
- People between the ages of 50 and 80 (the trial aims for roughly half of participants to be older than 65)
- People who have reported having thoughts of suicide, as measured by a specific structured interview tool (confirm with trial site for exact scoring details)
- People who have been diagnosed with Major Depressive Disorder using a standardised clinical interview
- People whose depression scores 16 or higher on a recognised depression rating scale called the MADRS
- People who score 23 or higher on a standard memory and thinking test called the Mini Mental Status Exam
- People who are either not taking antidepressants, or who have been on a stable antidepressant dose for at least 8 weeks and do not plan to change that dose during the study period, and who are not currently receiving one-on-one talk therapy
- People who have the ability to understand and agree to research assessments and treatment
Who may not be able to join:
- People who currently have a plan or intention to attempt suicide in the near future
- People who have, or have had, a psychiatric diagnosis other than Major Depressive Disorder (without psychotic features), generalised anxiety disorder, or a specific phobia
- People taking psychiatric medications or cholinesterase inhibitor drugs, except for those taking 0.5 mg or less of lorazepam per day (up to seven times per week)
- People with neurological conditions such as dementia, Parkinson's disease, epilepsy, or certain types of mild cognitive impairment
- People who have had a serious medical illness in the past 3 months — such as a stroke, heart attack, major surgery, organ failure, metastatic cancer, or similar conditions — that could be contributing to depression, affecting the brain, or making study participation difficult
- People who cannot safely have an MRI scan, including those with a pacemaker, heart valve replacement, vascular stent, insulin pump, cochlear implant, other metal implants in the body, or those who experience claustrophobia (fear of enclosed spaces)
Important: Always verify eligibility with the trial site directly before applying.
Based on publicly available eligibility criteria from ClinicalTrials.gov. Verify directly with the trial site before acting. This is not medical advice.
Contact this trial
Principal Investigator: Nili Solomonov, PhD, Weill Medical College of Cornell University
Phone: (914) 682-9100
Contact details sourced from ClinicalTrials.gov. Verify directly with the trial site before attending.
GP referral letter
Print a one-page summary to share with your doctor.
Trial details
Where this trial is recruiting
Primary endpoints
Change in resting state functional connectivity of the Positive Valence System; Change in STAR task reaction time following social feedback
Can't join this trial?
Data last synced from ClinicalTrials.gov: 8 July 2026. Trial status can change. Always verify current status directly with the trial site before making any decision.