Phase 2 Mesothelioma Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• You have a type of cancer called malignant pleural mesothelioma (MPM) that a specialist surgeon believes may be removable with surgery, based on scans showing the cancer has not spread beyond one side of the chest
• You are willing to undergo planned surgery to remove the tumor (one of two types of chest surgery)
• Your mesothelioma can be any cell type (epithelial, mixed, or sarcomatoid)
• The cancer may or may not have spread to nearby lymph nodes
• You are over 18 years old
• You are generally well enough to carry out light activity and care for yourself (confirm with trial site)
• Your blood counts, liver, and kidney function are within acceptable ranges as shown by blood tests
• If you are a woman who could become pregnant, you must have a negative pregnancy test before joining
• You weigh more than 30 kg (about 66 lbs)
• You are willing and able to attend all required appointments and follow the study schedule

Who may not be able to join:

• You have previously been treated with certain immunotherapy drugs that target PD-1, PD-L1, or CTLA-4 pathways, including durvalumab
• You have taken part in another clinical trial with an experimental drug in the last 3 months
• You received any anti-cancer treatment less than 28 days before joining the study
• You have certain heart rhythm abnormalities detected on a heart tracing (ECG) (confirm with trial site)
• You have been taking immune-suppressing medications in the 28 days before starting the study (with some exceptions such as low-dose steroid inhalers or very low-dose oral steroids)
• You have unresolved significant side effects from a previous cancer treatment (for a cancer other than MPM)
• You previously had a serious immune-related reaction to immunotherapy
• You have an autoimmune condition that requires strong immune-suppressing medication
• You have a history of lung inflammation caused by the immune system, or currently have lung inflammation
• You have a history of a condition where your immune system does not work properly from birth
• You have had an organ transplant from another person
• You have had a serious reaction to immunotherapy drugs in the past
• You have a serious heart condition or other severe uncontrolled medical problem
• You have HIV, AIDS, active hepatitis B, or another serious ongoing infection requiring treatment
• You currently have an active infection requiring antibiotics, antifungal, or antiviral drugs (preventive antibiotics are usually acceptable)
• You have a history of cancer spreading to the membranes around the brain or spinal cord
• You received a live vaccine within 30 days before starting the study
• You are pregnant, breastfeeding, or not using effective birth control (if able to have children)
• You have brain metastases that are causing symptoms or require active treatment
• You have uncontrolled seizures
• You are female and of reproductive potential without a negative pregnancy test at study entry
• No tumor tissue sample can be obtained during an initial surgical procedure (thoracoscopy)

Important: Always verify eligibility with the trial site directly before applying.