Phase 3 Lung Cancer Trial, Not Yet Recruiting NCT05990127 Sponsor: Akeso Condition: Lung Cancer
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Phase 3 Lung Cancer Trial, Not Yet Recruiting

NCT05990127
Not Yet Recruiting Phase 3

voxsanity.com.au · Eligibility summary from public government registries · 18 August 2026 · not medical advice

Who may and may not be able to join

AI generated eligibility summary. Written by an AI model from the official source data and checked on a sample basis. It can contain mistakes, so confirm anything important against the original source. How we use AI

Who may be able to join

  • People who have voluntarily agreed to take part and have signed a written informed consent form.
  • People aged 18 years or older at the time of signing the consent form.
  • People whose general health and ability to carry out daily activities is rated as fully active or restricted only in physically strenuous activity (an ECOG score of 0 or 1).
  • People with a life expectancy of at least 3 months.
  • People who have been confirmed through tissue or cell testing to have locally advanced (Stage IIIB or IIIC) or metastatic (Stage IV) non-small cell lung cancer (NSCLC), where surgery to fully remove the cancer is not possible and intensive combined radiation and chemotherapy treatment is also not suitable.
  • People who have not previously received any systemic (whole-body) treatment for advanced or metastatic NSCLC.
  • People whose cancer tests show a PD-L1 score of less than 1% (a measure of a specific protein on cancer cells) (confirm with trial site).
  • People whose cancer does not carry specific gene changes known as EGFR sensitive mutations or ALK gene translocations.

Who may not be able to join

Each point below is a reason the trial team may not be able to accept someone. It is not a list of requirements to meet.

  • People whose lung cancer has been confirmed as small cell lung cancer (SCLC).
  • People with NSCLC that has specific gene mutations for which approved targeted treatments already exist.
  • People who currently have active cancer that has spread to the brain or spinal cord.
  • People who have received radiation treatment to the lungs at a dose greater than 30 Gy within the 6 months before the first dose of the study treatment.
  • People who have had another active cancer within the past 5 years, except for the lung cancer being studied or certain localised cancers that have been fully treated (confirm with trial site).
  • People who are pregnant or currently breastfeeding.
  • People with significant heart or blood vessel disease affecting the heart or brain.
  • People with a known history of severe allergic reactions to other monoclonal antibody treatments, or a known allergy or hypersensitivity to any of the study drugs or their ingredients.
  • People who have an active autoimmune disease (where the immune system attacks the body) that required systemic treatment within the past 2 years, or an autoimmune condition that may return or need planned treatment, as assessed by the treating doctor.
  • People with known active tuberculosis affecting the lungs.
  • People with active hepatitis B or active hepatitis C infection.
  • People with a known medical history of immune deficiency, or a positive HIV test result.

Important: Always verify eligibility with the trial site directly before applying.

Based on publicly available eligibility criteria from ClinicalTrials.gov. Verify directly with the trial site before acting. This is not medical advice.

This is a simplified plain English summary of the eligibility criteria. Full criteria are set by the trial investigators and may include additional requirements not shown here. Never self-exclude from a trial based on this summary. Contact the trial site directly to confirm your eligibility.
Last synced 20 July 2026

Contact this trial

Principal Investigator: Jie Wang, M.D., Cancer hospital, Chinese academy of medical sciences and Peking union medical college

Phone: +86-0760-89873999

Contact details sourced from ClinicalTrials.gov. Verify directly with the trial site before attending.

GP referral letter

Print a one-page summary to share with your doctor.

Trial details

Status
Not Yet Recruiting
Phase
Phase 3
Sponsor
Akeso
Registry
ClinicalTrials.gov
Start date
14 November 2023
Est. completion
5 August 2025

This date has passed while the registry still lists the trial as open to participants. Sponsors often update a trial's status without revising its projected end date, so it may well still be recruiting — but the record is out of date in at least one respect. Check with the study contact before relying on either.

Where this trial is recruiting

🇨🇳 China

Primary endpoints

Overall Survival(OS); Progression-Free Survival(PFS) by investigator(INV)

Can't join this trial?

Expanded access pathways

If this trial is not available to you, other access pathways may exist. In Australia, the TGA Special Access Scheme allows access to unapproved therapeutic goods for individual patients.

TGA Special Access Scheme information

Find other recruiting trials on ClinicalTrials.gov

Data last synced from ClinicalTrials.gov: 20 July 2026. Trial status can change. Always verify current status directly with the trial site before making any decision.

Trial recruitment status can change without notice between our nightly data updates. Always contact the trial site directly to confirm current recruitment status before making any decisions or travel arrangements.

View original record on ClinicalTrials.gov