Phase 3 Colorectal Cancer Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People aged 18 to 70 years
• People whose rectal cancer has been confirmed by a tissue biopsy to be a type called adenocarcinoma
• People whose cancer has reached a certain stage of growth or has spread to nearby lymph nodes, but has not spread to distant parts of the body (based on the 8th edition of a standard cancer staging system)
• People who have at least one area of cancer that can be measured on a scan, according to standard criteria
• People who are fully active or have only minor restrictions on physical activity (based on a standard performance scale scored 0 or 1)
• People whose doctors estimate they are likely to live at least 6 more months
• People whose blood test results show that the heart, liver, kidneys, and bone marrow are all functioning within acceptable ranges (confirm with trial site for specific values)
• People who are willing to take part, have signed a consent form, and are able to follow the study schedule and attend follow-up appointments

Who may not be able to join:

• People who have had, or currently have, another type of cancer within the past 5 years
• People who have a known allergy or sensitivity to any of the medicines used in this trial
• People who have a weakened immune system, whether from birth or due to a condition such as HIV infection
• People who have an active or suspected autoimmune disease (such as lung inflammation, eye inflammation, bowel inflammation, liver inflammation, joint disease, kidney inflammation, or thyroid problems, among others); people with vitiligo may still be considered, but people with asthma requiring medication to keep airways open may not be eligible (confirm with trial site)
• People who have an active infection that requires treatment with medicines taken throughout the body (such as oral or intravenous antibiotics)
• People who have previously received certain types of immunotherapy medicines that target PD-1, PD-L1, or CTLA-4 pathways
• People who still have side effects from a previous treatment that are above a mild level (except for hair loss)
• People who have a history of heart attack, stroke, unstable chest pain, serious heart failure, or blood clots in a deep vein
• People who have had major surgery, a serious injury, a bone fracture, or have an unhealed wound or ulcer within the past 4 weeks
• Women who are pregnant or breastfeeding
• People with significant liver or kidney problems
• People with a history of misusing mind-altering substances and who are unable to stop, or people with a diagnosed mental health disorder
• People who have taken part in another clinical drug trial within the past 4 weeks
• People who have other health conditions that the trial doctor believes could seriously affect their safety or their ability to complete the study
• People whom the trial doctor judges would not receive the most benefit from taking part in this study

Important: Always verify eligibility with the trial site directly before applying.