Phase 2 Mesothelioma Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• You must already be enrolled in a related study called BASECAMP-1, with tumor tissue showing a specific genetic marker (called "loss of HLA-A*02"), and have had a successful blood collection process with enough cells stored for treatment
• You have been diagnosed with one of these cancers that has come back, cannot be removed by surgery, has spread, or is advanced: colorectal cancer, non-small cell lung cancer, pancreatic cancer, ovarian cancer, mesothelioma, or another solid tumor that produces a protein called mesothelin — and your tumor must be measurable (at least 1 cm) on a CT scan
• You have already received the standard treatments required for your type of cancer, as outlined in the study plan
• Your major organs (such as kidneys, liver, and heart) are working well enough, as confirmed by tests described in the study plan
• You are able to carry out normal daily activities with little or no limitation (confirm with trial site for exact fitness level required)
• Your doctor expects you to live for at least 3 more months
• You are willing and able to follow the study schedule, including long-term safety check-ins

Who may not be able to join:

• Your cancer could be treated with a local procedure, or you are still able to receive standard treatments that could potentially cure or meaningfully treat your cancer (not just manage symptoms)
• You have previously received a bone marrow or stem cell transplant from another person
• You have previously received a transplanted organ (such as a kidney or liver)
• You have mesothelioma that has spread from the chest lining into the abdomen
• You have received cancer treatment within 3 weeks (or 3 half-lives of the drug) before the planned cell infusion
• You have received radiation therapy within 28 days before the planned cell infusion
• You have had a serious heart problem — such as unstable chest pain, irregular heartbeat, or a heart attack — within the last 6 months
• You have had a new blood clot in your lungs or legs within the last 3 months (older, treated clots may be acceptable — confirm with trial site)
• You have a history of scarring or inflammation of the lungs (including from drugs or radiation) that needed long-term steroid or immune-suppressing treatment within the past year
• You need extra oxygen at home to help you breathe
• You are a woman who is pregnant or breastfeeding
• You are able to have children (male or female) and are not willing to use birth control from the time you join the study until 6 months after receiving the cell treatment

Important: Always verify eligibility with the trial site directly before applying.