Phase 2 Mesothelioma Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• You are 18 years of age or older (any sex)
• You have been diagnosed with a type of cancer called malignant peritoneal mesothelioma (MPM) at the enrolling hospital
• During surgery, a tissue sample has confirmed your mesothelioma is the "epithelioid" type (a specific subtype)
• Surgeons were able to remove all or almost all of the cancer during your procedure
• You are planning to have surgery to remove all the cancer spread inside the abdomen
• You are generally active and able to care for yourself, with only minor limitations on strenuous activity (confirm with trial site)
• Your blood cell counts are within an acceptable range — enough white blood cells and platelets
• Your kidneys are working well enough (based on a blood or urine test)
• Your liver is working well enough (based on a blood test)
• If you are a woman who could become pregnant, you have a negative pregnancy test and agree to use effective contraception throughout the study
• If you are a man, you agree to use a reliable barrier method of contraception (such as a condom) for the duration of the study
• You are willing and able to sign a consent form before any study procedures begin

Who may not be able to join:

• You have previously received chemotherapy given directly into the abdomen or through the bloodstream for peritoneal mesothelioma
• You have previously received chemotherapy containing platinum-based drugs (such as cisplatin or carboplatin)
• Your biopsy showed a different subtype of mesothelioma (sarcomatoid, well-differentiated papillary, or benign multicystic)
• You have had another cancer in the past, unless it was certain skin cancers, a fully treated cervical cancer in situ, another cancer with no signs of activity for more than three years, or a very slow-growing cancer being monitored (confirm with trial site)
• There is a strong suspicion the cancer has spread outside the abdomen
• You are pregnant or breastfeeding
• You have active heart artery disease (such as unstable chest pain or a recent abnormal heart stress test) — though those with a history of heart disease may still qualify with a recent normal stress test or a cardiologist's clearance
• You have uncontrolled high blood pressure (above 140/90) that has not been cleared for surgery
• You have moderate-to-severe heart failure or breathing problems that would make participation unsafe or difficult
• You have a history of stroke or other brain blood vessel disease that would make participation unsafe or difficult
• You have other serious health conditions unrelated to your cancer that would make full participation unsafe or difficult
• You have a known allergy to cisplatin, carboplatin, pemetrexed, or mitomycin (chemotherapy drugs used in the trial)
• At the time of surgery, extensive internal scarring (adhesions) prevents chemotherapy from being delivered inside the abdomen
• Any other condition that would prevent the chemotherapy from being safely given inside the abdomen
• You take an oral medication that cannot be substituted and that would be unsafe to stop for up to ten days
• Your life expectancy is estimated to be less than 12 weeks

Important: Always verify eligibility with the trial site directly before applying.