Phase 2 Myeloma Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• You have been diagnosed with multiple myeloma, and a tumor sample has tested positive for a specific protein called NY-ESO-1
• You have a specific genetic marker on your immune cells called HLA-A*02:01, HLA-A*02:05, or HLA-A*02:06 (found through a blood test)
• Your multiple myeloma has come back or stopped responding to treatment, and you have received at least 2 previous treatment regimens — including at least one from each of three specific drug types (a proteasome inhibitor, an immunomodulatory drug, and an anti-CD38 antibody)
• Your myeloma can still be measured through specific blood, urine, or protein tests, showing the disease is still active
• You have not received any myeloma treatment within 7 days before the preparation treatment (called lymphodepletion) begins (steroids are still allowed up to that point)
• You have had a previous stem cell transplant (your own or a donor's), which is allowed
• You have had previous cell-based therapy, as long as it did not target the NY-ESO-1 protein
• Your body has recovered from the side effects of your most recent myeloma treatment
• You are generally able to carry out basic daily activities (a doctor will assess this using a standard scale)
• Your kidneys are working at a reasonable level (confirm with trial site)
• Your liver function test results are within acceptable ranges
• Your bilirubin (a liver-related chemical) levels are within acceptable limits — slightly higher limits apply if you have a condition called Gilbert's syndrome
• You do not have liver scarring (cirrhosis) or fluid buildup in the abdomen (ascites)
• Your heart is pumping blood effectively (at least 50% efficiency on a scan)
• You do not have significant fluid around your heart or lungs
• You do not have uncontrolled heart rhythm problems or significant heart symptoms
• Your blood oxygen level is above 92% while breathing normal air
• You are between 18 and 80 years old
• You weigh at least 40 kg (about 88 lbs)
• Your blood counts (white cells, red cells, and platelets) meet minimum levels — with some flexibility if low counts are caused directly by the myeloma itself
• You are able and willing to use effective birth control during the study and for at least 3 months after it ends
• You are willing and able to sign a consent form and agree to long-term follow-up
• You have relapsed or treatment-resistant plasma cell leukemia and have had at least two previous treatment regimens (confirm with trial site)

Who may not be able to join:

• You have an active or uncontrolled infection at the time treatment is due to begin
• You have an autoimmune disease that affects the nervous system, such as multiple sclerosis
• You have received a live vaccine within the past 30 days
• You are currently taking antibiotics for an active infection
• You have had another type of cancer within the last 2 years that was not fully treated with the aim of curing it (some minor skin cancers or cervical conditions may still be acceptable — confirm with trial site)
• You have had a major operation within 28 days, or a minor operation within 14 days, before the preparation treatment begins — or you have a planned procedure that the doctor believes could put you at risk

Important: Always verify eligibility with the trial site directly before applying.