Early Phase 1 Parkinson's Disease Trial, Recruiting

Written by an AI model from the ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• You are between 50 and 80 years old
• You are able to sign a consent form agreeing to take part
• You can read, speak, and understand English
• You are willing and able to take part in one brain scanning session (PET/MRI)

If you have Parkinson's disease (PD), you also need to:

• Have an existing diagnosis of Parkinson's disease based on standard criteria
• Have been on stable medications for at least 30 days
• Have a disease stage between I and IV on a standard Parkinson's rating scale (confirm with trial site)
• Have a family member or caregiver who can answer questions about your daily activities

If you have Multiple System Atrophy (MSA), you also need to:

• Have an existing diagnosis of MSA based on standard criteria
• Have been on stable medications for at least 30 days
• Have either the movement-focused or balance/coordination-focused type of MSA (confirm with trial site)
• Have a family member or caregiver who can answer questions about your daily activities

If you have Dementia with Lewy Bodies (DLB), you also need to:

• Have an existing diagnosis of probable DLB based on standard criteria
• Have been on stable medications for at least 30 days
• Have a mild level of cognitive impairment or less, based on a standard memory and thinking scale (confirm with trial site)
• Have a family member or caregiver who can answer questions about your daily activities

Who may not be able to join:

• You have risk factors for heart or blood vessel disease (such as high blood pressure or high cholesterol) that are not well managed
• You have a major psychiatric condition such as schizophrenia
• You have a history of stroke
• A previous brain scan has shown specific areas of damage in your brain
• You have a history of serious illness, including major kidney or liver problems or a significant brain or nerve condition
• You have had major surgery in the past 6 months
• You have a history of head injury from an external force, such as a blow to the head, a blast, or a penetrating injury
• You have problems with urination that are not being treated or managed
• You have a current or past diagnosis of bipolar disorder or certain other mental health conditions (note: treated depression is allowed)
• You currently misuse drugs or alcohol
• You are unable to lie flat and still for up to 90 minutes during the scan
• You are pregnant or breastfeeding
• You have metal objects in your body that could be affected by the MRI scanner, or you have a fear of enclosed spaces that would prevent you from having an MRI
• You have recently been exposed to radiation from other research scans, and combining that with this study would exceed safe limits
• You have certain metal implants in your body, such as aneurysm clips, artificial heart valves with metal parts, metal fragments, shrapnel, or ferromagnetic (metal-attracting) jewellery or clothing clips
• You have an electrical implant such as a heart pacemaker or a medication pump
• You have a medical condition that increases your risk of seizures, severe anxiety in enclosed spaces, or cardiac arrest
• You are unable to lie comfortably on a flat bed inside the scanner for 60 to 90 minutes due to conditions such as back pain or arthritis
• You are a woman of childbearing age and do not have a negative pregnancy blood test on the day of the scan
• You weigh more than 300 lbs (the weight limit for the MRI table)

If your participation involves a blood draw through an arterial line during the scan, you may also not be able to join if:

• A standard circulation test on both your hands gives an abnormal result (confirm with trial site)
• You have Raynaud's syndrome (a condition affecting blood flow to the fingers)
• You have a bleeding disorder
• You take blood-thinning medications such as Coumadin, Plavix, or Lovenox
• You have an allergy to Lidocaine (a local anaesthetic)

Important: Always verify eligibility with the trial site directly before applying.