Phase 3 Parkinson's Disease Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

Healthy volunteers (ages 18–85) may be eligible if they:

• Are willing to give written consent to participate.
• Are using a highly effective form of birth control.
• Are in good general health based on medical history, physical exam, and lab tests.
• Have no history of major neurological, mental health, or other significant medical conditions.
• Have a normal or near-normal brain MRI scan (minor findings may be acceptable for those aged 60 and over).

People with Parkinson's Disease (ages 45–85) may be eligible if they:

• Have a confirmed Parkinson's disease diagnosis based on recognised medical diagnostic guidelines.
• Have had motor symptoms for either less than 5 years or 5 years or longer (two separate groups are being studied).
• Have had a previous brain scan (PET or SPECT) that showed abnormal results related to dopamine function.
• Are able to understand the study information and provide written consent.

People with Multiple System Atrophy – Parkinsonian type (MSA-P, ages 45–85) may be eligible if they:

• Have a confirmed or probable MSA-P diagnosis based on recognised medical diagnostic guidelines.
• Have had a previous brain scan (PET or SPECT) that showed abnormal results related to dopamine function.
• Are able to understand the study information and provide written consent.

People with Alzheimer's Disease dementia (ages 50–85) may be eligible if they:

• Have a diagnosis of probable Alzheimer's disease with supporting evidence of the disease process.
• Are able to understand the study information and provide written consent.

People with Dementia with Lewy Bodies (ages 50–85) may be eligible if they:

• Have a diagnosis of probable Dementia with Lewy Bodies.
• Have had a previous brain scan (PET or SPECT) that showed abnormal results related to dopamine function.
• Are able to understand the study information and provide written consent.

Who may not be able to join:

For healthy volunteers:

• People with major health conditions that could interfere with the study tests.
• People with any signs of memory or thinking problems.
• People with a history of mental health conditions.
• People who use illegal drugs or have a history of drug or alcohol misuse.
• People taking regular medications that could interfere with specific types of brain imaging used in this study.
• People who have been exposed to ionising radiation (such as from other research studies) above a certain level in the past 12 months.
• People who cannot have an MRI scan for any medical reason.
• People with claustrophobia or who cannot tolerate being in a confined space during the scan.
• People unwilling to avoid intense physical exercise around the time of the study.
• People who are pregnant or breastfeeding.
• People who do not agree to have unexpected findings from their scan shared with their GP.
• People with a failed Allen test (a blood flow check) or an allergy to a local anaesthetic called lidocaine — this applies only to those agreeing to an optional blood sampling procedure.

For people with Parkinson's Disease, MSA-P, Alzheimer's Disease, or Dementia with Lewy Bodies:

• People with neurological or psychiatric conditions other than their primary diagnosis.
• People with significant other health conditions, particularly diabetes or heart disease.
• People with a certain level of white matter changes or other notable abnormalities on their brain MRI scan (confirm with trial site).
• People with a history of alcohol or drug misuse.
• People who have previously taken part in research studies involving radiation exposure.
• People who cannot have an MRI scan for any medical reason.
• People with claustrophobia or who cannot tolerate being in a confined space during scanning.
• People unwilling to avoid intense physical exercise around the time of the study.
• People who are pregnant or breastfeeding.
• People who do not agree to have unexpected findings from their scan shared with their GP.
• People taking blood-thinning medications (anticoagulants).

Important: Always verify eligibility with the trial site directly before applying.