Phase 1 Pancreatic Cancer Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• You have been diagnosed with pancreatic cancer (a specific type called adenocarcinoma) that is either "borderline resectable" (possibly removable by surgery) or "locally advanced" (spread nearby but not to distant parts of the body), and surgery is not expected to require removal or rebuilding of a major artery.
• If your cancer is borderline resectable, you must have already completed standard chemotherapy, finishing between 1 and 3 weeks before starting this trial's treatment (if you fall outside this window, an extra round of chemotherapy may allow you to qualify — confirm with trial site).
• You are at least 18 years old.
• You are well enough to carry out basic daily activities (your doctor will assess this using a standard scale).
• Your blood counts, liver, kidney, and other organ functions meet certain minimum levels based on blood tests (your doctor will check these).
• You are able to swallow pills.
• Your blood clotting levels are within an acceptable range, or if you are already on blood thinners, your levels are within the safe range for that medication.
• If you could become pregnant, or if you are a man who could father a child, you agree to use at least one highly effective form of birth control from the start of the study until 30 days after your last dose of the study drug.
• You agree to follow certain lifestyle guidelines during the study.
• You are able to understand and sign a consent form agreeing to take part (a legal representative may do this on your behalf if needed).

Who may not be able to join:

• You have received treatment for pancreatic cancer in the past 2 years, other than the chemotherapy given for your current diagnosis.
• You have another cancer (past or current) that could affect how safely or accurately the trial can be evaluated (confirm with trial site if you have a history of another cancer).
• You are currently taking part in another clinical trial or have used an experimental treatment or device within the past 3 months.
• You have had a serious allergic reaction to a drug similar to the study drug or other medicines used in this trial.
• You have an uncontrolled ongoing illness, such as an active infection (including unresolved COVID-19 symptoms within the past 2 weeks), or a long-term condition that is not well managed.
• You have significant heart problems, such as severe heart failure, unstable chest pain, a heart attack within the past 12 months, a serious heart rhythm problem, or a condition called long QT syndrome.
• You are still experiencing side effects from your induction chemotherapy that have not returned to a mild or baseline level (with some exceptions for hair loss and certain lab values).
• You have had major surgery within the past 3 weeks, or you have not yet recovered from a major surgery.
• You have a buildup of fluid around your lungs, heart, or abdomen that needs to be drained at least once a month (though a permanent drainage tube may be acceptable — confirm with trial site).
• You have had a stroke within the past 2 years.
• You have a history of a condition where your liver cannot filter toxins, causing confusion or other brain symptoms (hepatic encephalopathy).
• You have a significant bleeding disorder or problem with blood clotting (when not caused by blood-thinning medication).
• You have a condition that affects how your body absorbs food or medication, such as a long-term digestive or gut disorder.
• You are pregnant or breastfeeding, or you are of childbearing age and cannot confirm a negative pregnancy test within 5 days of starting the study.
• You have HIV that is not well controlled with medication, or your HIV viral load has not been undetectable for at least 6 months.
• You have hepatitis B that can still be detected in your blood while on treatment to suppress it.
• You have hepatitis C that has not been successfully treated and cleared, or that is currently detectable in your blood.

Important: Always verify eligibility with the trial site directly before applying.