Depression and Anxiety Trial, Recruiting

Written by an AI model from the ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People who are willing and able to give consent to participate in the study
• People who are 18 years old or older
• People who can speak and read English
• People whose main diagnosis is a major depressive episode without psychotic features in the current episode, confirmed by a specific psychiatric interview tool
• People whose depressive symptoms have not improved after trying at least one antidepressant at an appropriate dose during the current episode
• People with at least moderate depression symptoms, as measured by a score of 15 or higher on a standard depression rating scale called the Grid HRSD-17
• People who have been referred for a brain stimulation treatment called rTMS by their treating doctor, and who have chosen to go ahead with this treatment
• People who are able to attend and keep to the treatment schedule
• People who have been on a stable dose of psychiatric medications (including prescribed cannabis) or a stable therapy program for at least four weeks before entering the trial
• People aged 65 or older who score 24 or above on a standard memory and thinking test (adjusted for education level)

Who may not be able to join:

• People who have been diagnosed with bipolar I or II disorder
• People who have had a substance use disorder (not including caffeine or nicotine) or alcohol use disorder in the past three months, except that mild cannabis or alcohol use disorder in the past three months may be permissible — moderate to severe would not be (confirm with trial site)
• People who are currently using illegal substances or cannabis for non-medical reasons, as confirmed by a urine test
• People who have a serious unstable medical or neurological condition, such as uncontrolled diabetes or kidney problems
• People whose depression symptoms have a physical medical cause, such as a thyroid condition, as determined by their referring doctor
• People who are at immediate risk of suicide or whose life is at risk due to self-neglect
• People who are pregnant, breastfeeding, or planning to become pregnant during the course of the treatment (pregnancy is checked by a urine test)
• People who have a medical reason they cannot receive TMS, such as a personal history of epilepsy or seizures, a metal implant in the head, or a pacemaker
• People who are not willing to continue their current antidepressant medication during the trial
• People who are taking more than 1 mg of lorazepam per day, or an equivalent amount of a similar medication
• People who have any other condition that the study investigators believe would affect their ability to complete the study
• People who have any medical reason they cannot have an MRI scan
• People who have had a course of electroconvulsive therapy (ECT) that did not work during the current depressive episode (having had unsuccessful ECT in a previous episode does not exclude someone)

Important: Always verify eligibility with the trial site directly before applying.