Phase 2 Myeloma Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People aged 18 or older
• People who have been diagnosed with multiple myeloma, confirmed by a bone marrow test showing at least 10% abnormal plasma cells, along with measurable levels of the abnormal protein the disease produces (detectable in blood or urine tests)
• People whose multiple myeloma has come back after treatment, or whose disease did not respond well enough to treatment (known as relapsed or refractory myeloma)
• People whose general physical functioning is rated at a reasonable level based on a standard medical assessment scale (ECOG score of 0, 1, or 2 — confirm with trial site)
• People who are expected to live for at least 3 more months
• People (or their legal guardian) who are able to read, understand, and sign a consent form

Who may not be able to join:

• People who are currently taking part in, or planning to join, another interventional clinical trial
• People the trial doctor considers unsuitable for the study for any reason
• People with a form of myeloma that does not produce measurable abnormal proteins (called non-secretory myeloma)
• People who have received any myeloma treatment within approximately 2 weeks before starting the trial, or who have recently received high doses of steroid medications such as prednisone or dexamethasone
• People who had a donor stem cell transplant within the past year and have not stopped taking immune-suppressing medications at least one month before joining
• People with low blood counts — specifically, very low platelet or white blood cell levels
• People with significant lung disease, including severe chronic obstructive pulmonary disease (COPD) with poor lung function test results, or moderate-to-severe asthma that has not been well controlled in the past 2 years
• People with significant heart problems, including a heart attack within the past 6 months, uncontrolled heart failure or chest pain, certain heart rhythm problems, or an abnormal heart electrical reading above a specific threshold on an ECG
• People with severe liver problems, unless caused by the myeloma itself
• People whose kidneys are not filtering blood adequately (confirm specific threshold with trial site)
• People with a known allergy to the trial treatment or to similar types of medications
• People with serious uncontrolled medical conditions such as uncontrolled diabetes, active infections, or uncontrolled high blood pressure
• People known to be HIV positive, or who have active hepatitis B or C infection
• People who have had another cancer in the past 5 years, with some exceptions such as certain skin cancers or cancers considered fully cured with very low chance of return
• People who may have difficulty following the study requirements due to conditions such as alcohol dependence, drug dependence, or psychological disorders, or where the trial doctor believes participation would not be in the person's best interest
• People who are pregnant or breastfeeding
• People with significant nerve damage in their hands or feet at a certain level of severity (confirm with trial site)

Important: Always verify eligibility with the trial site directly before applying.