Phase 2 Lung Cancer Trial, Not Yet Recruiting NCT06185400 Sponsor: Cancer Institute and Hospital, Chinese Academy of Medical Sciences Condition: Lung Cancer
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Phase 2 Lung Cancer Trial, Not Yet Recruiting

NCT06185400
Not Yet Recruiting Phase 2

voxsanity.com.au · Eligibility summary from public government registries · 18 August 2026 · not medical advice

Who may and may not be able to join

AI generated eligibility summary. Written by an AI model from the official source data and checked on a sample basis. It can contain mistakes, so confirm anything important against the original source. How we use AI

Who may be able to join

  • People aged 18 or older, of any gender.
  • People who have been diagnosed with locally advanced or metastatic non-small cell lung cancer (a type of lung cancer) that has been confirmed by laboratory testing and is not suitable for surgery or radiation therapy to cure it.
  • People whose lung cancer has a specific change in a gene or protein called HER2 — this includes mutations in the HER2 gene, extra copies of the HER2 gene, or too much HER2 protein being produced.
  • People who have not yet received any systemic (whole-body) treatment for their advanced lung cancer (for one treatment group in this trial).
  • People who previously received a specific type of targeted therapy called a third-generation EGFR-TKI as their first treatment, and whose cancer has shown only limited or slow growth in certain areas, and who the research team believes could still benefit from continuing that treatment (for a second treatment group in this trial).
  • People who previously received a specific type of targeted therapy called a third-generation EGFR-TKI as their first treatment, and whose cancer has progressed more widely, and who the research team believes are unlikely to continue benefiting from that treatment (for a third treatment group in this trial).
  • People who have at least one area of cancer in the body that can be measured using standard imaging criteria at the start of the trial.
  • People with a general health and activity level rated as 0 or 1 on a standard scale used by doctors — meaning fully active or able to carry out light activity (confirm with trial site).

Who may not be able to join

Each point below is a reason the trial team may not be able to accept someone. It is not a list of requirements to meet.

  • People who have cancer that has spread to the brain or the lining around the brain and is causing symptoms.
  • People with a known allergy or intolerance to any ingredient in the study drugs being used in this trial.
  • People who have a history of serious heart or cardiovascular disease.
  • People who have a history of a lung condition called interstitial lung disease, or a similar condition caused by a drug, that required treatment with steroids, or who have had radiation-related lung inflammation.
  • People who have a history of neurological (brain or nerve) conditions or mental health disorders, including epilepsy or dementia.
  • People who are pregnant or currently breastfeeding.
  • People who the research team considers unsuitable for the trial for any other reason.

Important: Always verify eligibility with the trial site directly before applying.

Based on publicly available eligibility criteria from ClinicalTrials.gov. Verify directly with the trial site before acting. This is not medical advice.

This is a simplified plain English summary of the eligibility criteria. Full criteria are set by the trial investigators and may include additional requirements not shown here. Never self-exclude from a trial based on this summary. Contact the trial site directly to confirm your eligibility.
Last synced 30 July 2026

Contact this trial

Phone: 010-87788219

Contact details sourced from ClinicalTrials.gov. Verify directly with the trial site before attending.

GP referral letter

Print a one-page summary to share with your doctor.

Trial details

Status
Not Yet Recruiting
Phase
Phase 2
Sponsor
Cancer Institute and Hospital, Chinese Academy of Medical Sciences
Registry
ClinicalTrials.gov
Start date
1 February 2024
Est. completion
1 July 2025

This date has passed while the registry still lists the trial as open to participants. Sponsors often update a trial's status without revising its projected end date, so it may well still be recruiting — but the record is out of date in at least one respect. Check with the study contact before relying on either.

Primary endpoints

Percentage of Participants With Objective Response Rate (ORR) Based on Investigator Assessment Following Treatment in Participants With HER2 alterations Non-Small-Cell Lung Cancer (NSCLC)

Can't join this trial?

Expanded access pathways

If this trial is not available to you, other access pathways may exist. In Australia, the TGA Special Access Scheme allows access to unapproved therapeutic goods for individual patients.

TGA Special Access Scheme information

Find other recruiting trials on ClinicalTrials.gov

Data last synced from ClinicalTrials.gov: 30 July 2026. Trial status can change. Always verify current status directly with the trial site before making any decision.

Trial recruitment status can change without notice between our nightly data updates. Always contact the trial site directly to confirm current recruitment status before making any decisions or travel arrangements.

View original record on ClinicalTrials.gov