Phase 2 Colorectal Cancer Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People who have been confirmed by tissue testing to have a type of bowel cancer called colorectal adenocarcinoma.
• People whose colorectal cancer has spread to other parts of the body, as confirmed by CT scan and MRI.
• People who have already received a first round of chemotherapy that included a drug called oxaliplatin, with or without other cancer treatments such as targeted therapy, immunotherapy, or radiotherapy.
• People aged 18 to 70 years old.
• People who are in good enough general health to carry out daily activities with little or no limitation (as measured by a standard health scoring tool), and whose health has not noticeably declined in the two weeks before starting the trial.
• People whose blood and organ function results fall within acceptable ranges, including healthy enough levels of red blood cells, white blood cells, platelets, and normal or near-normal kidney and liver function (confirm with trial site for exact values).
• People who have read and signed a consent form agreeing to take part.

Who may not be able to join:

• People whose bowel cancer is a type other than adenocarcinoma, such as squamous carcinoma, neuroendocrine carcinoma, or adenosquamous carcinoma.
• People who have had a serious allergic reaction to the study drugs irinotecan or trifluridine/tipiracil (TAS-102), or to any of their ingredients — or people whose cancer got worse while they were being treated with irinotecan (note: people whose cancer progressed only during a maintenance phase of treatment may still be considered eligible — confirm with trial site).
• People who have had a serious allergic reaction to the drug bevacizumab or any of its ingredients.
• People who are unable to swallow tablets or who have conditions that prevent proper absorption of oral medication.
• People who have had repeated episodes of bleeding or who needed a blood transfusion in the two weeks before starting the trial.
• People who have had major surgery within the four weeks before joining the trial (routine tissue biopsies are not included in this restriction).
• People who have been diagnosed with another cancer within the past five years, with some exceptions for certain low-risk or fully treated cancers such as early cervical cancer, certain skin cancers, early bladder cancer, or well-treated thyroid cancer (confirm with trial site).
• People who have had serious bowel or digestive problems in the six months before starting the trial, such as a hole in the bowel, bowel blockage, a fistula (an abnormal internal tunnel), ongoing diarrhoea, Crohn's disease, or ulcerative colitis.
• People with serious heart problems, such as poor heart pumping function, heart failure, severe chest pain, or a history of stroke or heart attack in the past six months.
• People with blood pressure that remains very high despite treatment, or blood sugar levels that are not well controlled.
• People with a history of certain serious heart rhythm problems (confirm with trial site for specific conditions).
• People with active hepatitis B, hepatitis C, syphilis, or HIV infection.
• People who have had a blood clot in a vein or artery, such as a deep vein thrombosis or a clot in the lungs, within three months before starting the trial (clots related to medical catheters may be exempt — confirm with trial site).
• People who are currently being treated for tuberculosis, or who have been treated for it within the past 12 months.
• People with serious lung disease or a history of lung inflammation (pneumonitis).
• People who have an active infection requiring treatment in the two weeks before starting the trial.
• People with a history of psychiatric illness related to substance abuse, or a history of drug misuse.
• People who are pregnant or breastfeeding.
• People who are able to have children but are unwilling to use contraception during the trial.
• People with any other serious health condition, abnormal test result, or other concern that the trial doctor considers would make participation unsafe or affect the reliability of the results.

Important: Always verify eligibility with the trial site directly before applying.