Phase 1 Pancreatic Cancer Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• You are willing to sign a consent form and agree to follow all study requirements for the full duration of the trial
• You have been diagnosed with pancreatic ductal adenocarcinoma (a specific type of pancreatic cancer) confirmed by a tissue or cell sample
• You are older than 18 years of age
• Your cancer has not spread to other parts of the body but cannot be removed by surgery, and meets specific criteria about how the tumor touches nearby blood vessels (confirm with trial site)
• You are well enough to carry out daily activities, based on a standard health scale used in cancer care (confirm with trial site)
• Your blood counts, kidney function, and liver function meet certain minimum levels as measured by blood tests (confirm with trial site)
• You have already completed at least 4 months of one of the standard chemotherapy treatments recommended for pancreatic cancer (such as modified FOLFIRINOX, gemcitabine + nab-paclitaxel, or NALIRIFOX)
• You have had high-quality CT and/or MRI scans of your abdomen, chest, and pelvis within the last 30 days showing no sign that the cancer has spread
• You have had a special type of full-body scan (FDG-PET scan) at some point since your diagnosis to check for cancer spread
• Your tumor is small enough (less than 4 cm at its widest point) to be fully treated with the procedure used in this trial
• If you can become pregnant, you agree to use highly effective birth control for at least 1 month before and 1 month after the study treatment
• If you can cause a pregnancy, you agree to use effective contraception with your partner for 1 month after the study treatment

Who may not be able to join:

• You are currently pregnant or breastfeeding
• You have a known allergy to any ingredients in the study drug mitazalimab (L-Histidine, trehalose, or polysorbate 20)
• You have had a fever above 38°C (100.4°F) within 14 days before the study treatment
• You have taken part in another clinical trial or received an experimental treatment within the last 30 days
• You have previously been treated with a type of drug called a CD40 antibody
• You have a history of severe autoimmune disease (where the immune system attacks the body)
• You have metal markers or coils placed inside or near the tumor
• You have previously had radiation therapy to your pancreas
• You have a metal cardiac device (such as a pacemaker) implanted in your chest
• You have an uncontrolled irregular heartbeat that cannot be managed during the procedure (confirm with trial site)
• You are currently taking higher doses of steroid medications (such as prednisone above 10 mg/day) that cannot be stopped at least 2 weeks before treatment (lower or very short-term steroid use may be allowed — confirm with trial site)
• You have any health condition that would make major abdominal surgery under general anesthesia unsafe for you
• Your cancer has been found to have spread to distant parts of the body, including the lining of the abdomen, at any point during staging procedures

Important: Always verify eligibility with the trial site directly before applying.