Peripheral Neuropathy Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

Main participant groups (High-Risk and Low-Risk Cohorts):

• People aged 3 years or older.
• People who have been diagnosed with Neurofibromatosis Type 1 (NF1), either through clinical assessment or genetic testing.
• People with a diagnosis of mosaic or segmental NF1 (a form where only some cells or a specific area of the body is affected) are also eligible.
• Participants are placed into a High-Risk or Low-Risk group depending on whether they have certain additional characteristics, such as specific gene variants linked to a higher risk of nerve sheath tumours, a personal or family history of certain nerve tumours, a history of radiation treatment, a large growth called a plexiform neurofibroma, or the presence of a type of lesion called a distinct nodular lesion (DNL) — (confirm with trial site for full details of which group applies).
• The participant, or their parent, guardian, or legally authorised representative, must be willing and able to sign a consent form.

Parent/Guardian group:

• Parents or guardians of child participants aged 8 to 17 years who are enrolled in the High-Risk or Low-Risk groups.
• The parent, guardian, or legally authorised representative must be willing and able to sign a consent form for their own participation in this part of the study.

Who may not be able to join:

Main participant groups (High-Risk and Low-Risk Cohorts):

• People who are unable or unwilling to have MRI scans.

Parent/Guardian group:

• No exclusion criteria apply to this group.

Important: Always verify eligibility with the trial site directly before applying.