Phase 4 Hypertension Trial, Recruiting
Who may be able to join
AI generated eligibility summary. Written by an AI model from the official source data and checked on a sample basis. It can contain mistakes, so confirm anything important against the original source. How we use AI
Who might be able to join this trial:
- People aged 18 or older
- People with hard-to-control treatment-resistant high blood pressure, meaning their blood pressure remains too high (average 24-hour reading of 125 mmHg or more systolic, or 80 mmHg or more diastolic) even while consistently taking 3 or more blood pressure medications, including a water pill (diuretic) at an appropriate dose — or who are unable to tolerate a water pill
- People who agree to take part in all study procedures
Who may not be able to join:
- People with a known allergy or medical reason to avoid minocycline or similar antibiotics (tetracyclines)
- People who have used oral antibiotics in the past 3 months, are currently using them, or are expected to need them during the study
- People whose kidneys are not functioning well enough, based on a specific blood test result below a certain threshold (confirm with trial site)
- People whose high blood pressure is caused by another known medical condition
- People who have been hospitalised for a severe high blood pressure emergency within the past year
- People who have had two or more episodes in the past year of a sudden drop in blood pressure when standing up
- People who have had a heart attack, unstable chest pain, fainting, or a stroke in the past 6 months
- People with evidence of alcoholism or drug misuse
- People with serious ongoing conditions such as cancer or HIV/AIDS
- People who are currently pregnant or planning to become pregnant during the study
Important: Always verify eligibility with the trial site directly before applying.
Based on publicly available eligibility criteria from ClinicalTrials.gov. Verify directly with the trial site before acting. This is not medical advice.
Contact this trial
Principal Investigator: Steven M Smith, PharmD, MPH, University of Florida
Phone: 352-294-8297
Contact details sourced from ClinicalTrials.gov. Verify directly with the trial site before attending.
GP referral letter
Print a one-page summary to share with your doctor.
Trial details
Where this trial is recruiting
Primary endpoints
24-h systolic blood pressure; Gut microbiome; Gut inflammation and leakiness; Neuroinflammation
Can't join this trial?
Data last synced from ClinicalTrials.gov: 8 July 2026. Trial status can change. Always verify current status directly with the trial site before making any decision.