Colorectal Cancer Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• Adults aged 18 years or older
• People who have been diagnosed with locally advanced rectal cancer and have been assessed as suitable for a "watch and wait" approach (where treatment response is monitored rather than proceeding straight to surgery), based on international guidelines
• People whose cancer has been confirmed by biopsy as a specific type called adenocarcinoma (not the signet ring or mucinous subtypes), at certain stages of tumour and lymph node involvement, with limited spread to at most 1–2 organs or 1–2 spots in a single organ
• People whose cancer does not fully circle the rectum and where the affected length measures less than 7 cm
• People whose cancer is located in the lower or middle part of the rectum, within 7 cm of the anal opening
• People who have already received treatment aimed at a "watch and wait" outcome — such as total neoadjuvant therapy (TNT) or long-course radiation with chemotherapy, with or without brachytherapy — and who completed the TNT portion of treatment by March 2024 (this applies to the lookback portion of the study)
• People who have chosen not to take part in other ongoing intervention studies, such as the SCOTCH study or similar future studies
• People who agree to attend regular follow-up appointments and complete quality-of-life questionnaires
• People who have been lost to routine follow-up may still be considered if they completed treatment and are receiving follow-up care locally, and agree to participate by phone

Who may not be able to join:

• People who do not meet the inclusion criteria listed above

Important: Always verify eligibility with the trial site directly before applying.