Phase 1 Multiple Sclerosis Trial, By Invitation
voxsanity.com.au · Eligibility summary from public government registries · 18 August 2026 · not medical advice
Who may and may not be able to join
AI generated eligibility summary. Written by an AI model from the official source data and checked on a sample basis. It can contain mistakes, so confirm anything important against the original source. How we use AI
Who may be able to join
- People aged 18 or older.
- People who have been diagnosed with primary progressive MS (PPMS) or secondary progressive MS (SPMS) based on recognised diagnostic guidelines (the 2017 or 2010 Revised McDonald Criteria).
- People who, in the opinion of the trial investigator, are able to complete the study procedures.
- People who score 9 or higher on the Epworth Sleepiness Scale, a standard questionnaire used to measure daytime sleepiness.
- People who have been taking an approved disease-modifying therapy for MS at the same dose for at least 3 months before the screening visit.
- People whose treatments for mood and fatigue — both medication-based and non-medication-based — have remained unchanged for the 3 months before screening, and who intend to keep them unchanged for the duration of the trial.
Who may not be able to join
Each point below is a reason the trial team may not be able to accept someone. It is not a list of requirements to meet.
- People who fall asleep in under 15 minutes when trying to (sleep onset latency under 15 minutes).
- People whose mood or fatigue treatments — whether medication-based or non-medication-based — have changed in the 3 months before screening.
- People who, in the investigator's judgement, have a history of another significant medical condition that could interfere with the study or its results.
- People who have had a clinically significant abnormal blood test or physical finding that had not resolved by the baseline visit and that the investigator believes could affect study participation.
- People who test positive for cocaine or phencyclidine on a drug screen, or who have had known alcohol misuse within 30 days of the trial.
- People who are pregnant, have recently had a positive pregnancy test, are breastfeeding, or plan to become pregnant during the trial.
- People who are taking melatonin-related medications and have not completed an appropriate washout period, defined as either five half-lives of the medication or 14 days before screening, whichever is longer.
- People who have had a new or adjusted prescription medication within 14 days of the baseline visit.
- People who have had an MS relapse confirmed by an investigator within the past year.
- People in whom a gadolinium-enhancing demyelinating lesion (a type of active MS lesion visible on a specific type of MRI scan) has been found within the past year.
- People who have experienced optic neuritis (inflammation of the optic nerve) within the past 3 months.
- People whose work requires them to change their sleep schedule, such as those who work night shifts.
- People who have travelled across two or more time zones within 3 months of the screening visit.
Important: Always verify eligibility with the trial site directly before applying.
Based on publicly available eligibility criteria from ClinicalTrials.gov. Verify directly with the trial site before acting. This is not medical advice.
GP referral letter
Print a one-page summary to share with your doctor.
Trial details
This date has passed while the registry still lists the trial as open to participants. Sponsors often update a trial's status without revising its projected end date, so it may well still be recruiting — but the record is out of date in at least one respect. Check with the study contact before relying on either.
Where this trial is recruiting
Primary endpoints
Treatment Emergent Adverse Events (TEAEs)
Can't join this trial?
Data last synced from ClinicalTrials.gov: 9 July 2026. Trial status can change. Always verify current status directly with the trial site before making any decision.