Depression and Anxiety Trial, Recruiting NCT06273904 Sponsor: Medical University of South Carolina Condition: Depression and Anxiety
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Depression and Anxiety Trial, Recruiting

NCT06273904
Recruiting Not Applicable

Who may be able to join

AI generated eligibility summary. Written by an AI model from the official source data and checked on a sample basis. It can contain mistakes, so confirm anything important against the original source. How we use AI

Who might be able to join this trial:

  • You are between 18 and 65 years old
  • You have been diagnosed with an anxiety disorder (such as Generalized Anxiety Disorder, Panic Disorder, Social Anxiety Disorder, or a specific phobia), PTSD, OCD, or an adjustment disorder involving anxiety
  • You are currently looking for or receiving mental health treatment
  • You are able to read and understand a consent form and agree to take part
  • English is your first language or the main language you speak fluently

Who may not be able to join:

  • You have a moderate or severe alcohol or drug use problem (as defined by standard medical guidelines)
  • You have ever been diagnosed with a psychotic disorder or bipolar disorder with mania
  • You have a seizure disorder that would make brain stimulation or brain recording unsafe
  • You have ever had a traumatic brain injury that caused you to lose consciousness
  • You have a brain-related condition that gets worse over time, such as Alzheimer's disease, Parkinson's disease, or a similar condition
  • You have a health condition that would make it very uncomfortable to sit or lie still for long periods of time
  • You have any health reasons that would prevent you from having an MRI scan
  • You have metal anywhere in your body
  • You are currently pregnant
  • You experience severe anxiety in enclosed spaces (claustrophobia)
  • You are particularly sensitive to loud noises
  • You have a medical condition or take treatments that increase your risk of having a seizure
  • You have a history of severe brain injury
  • You have a history of seizures or epilepsy
  • You are currently taking certain medications, including anticholinergic drugs, antipsychotic medications, or sleeping/sedative medications (confirm with trial site if you are unsure whether your medication falls into these categories)
  • You are currently taking opiate-based medications or substances on a regular basis
  • You are currently taking naltrexone
  • Note: certain medications such as SSRIs, cholinesterase inhibitors, or NMDA receptor antagonists may be allowed if you have been on a stable dose for at least four weeks before joining the trial (confirm with trial site)

Important: Always verify eligibility with the trial site directly before applying.

Based on publicly available eligibility criteria from ClinicalTrials.gov. Verify directly with the trial site before acting. This is not medical advice.

This is a simplified plain English summary of the eligibility criteria. Full criteria are set by the trial investigators and may include additional requirements not shown here. Never self-exclude from a trial based on this summary. Contact the trial site directly to confirm your eligibility.
Last synced 26 July 2026
This study is not part of the standard drug-approval phase pathway (for example an observational, device, behavioural, or registry study), so a phase success rate does not apply.

Contact this trial

Principal Investigator: Christopher Sege, PhD, Medical University of South Carolina

Phone: (843) 501-1718

Contact details sourced from ClinicalTrials.gov. Verify directly with the trial site before attending.

GP referral letter

Print a one-page summary to share with your doctor.

Trial details

Status
Recruiting
Phase
Not Applicable
Registry
ClinicalTrials.gov
Start date
20 May 2024
Est. completion
1 January 2027

Where this trial is recruiting

🇺🇸 United States

Primary endpoints

Change in Fear-Potentiated Startle Reflex

Can't join this trial?

Expanded access pathways

If this trial is not available to you, other access pathways may exist. In Australia, the TGA Special Access Scheme allows access to unapproved therapeutic goods for individual patients.

TGA Special Access Scheme information

Find other recruiting trials on ClinicalTrials.gov

Data last synced from ClinicalTrials.gov: 26 July 2026. Trial status can change. Always verify current status directly with the trial site before making any decision.

Trial recruitment status can change without notice between our nightly data updates. Always contact the trial site directly to confirm current recruitment status before making any decisions or travel arrangements.

View original record on ClinicalTrials.gov