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Back to Atrial Fibrillation
Atrial Fibrillation Trial, Recruiting
NCT06299514
Who may be able to join
AI generated eligibility summary. Written by an AI model from the official source data and checked on a sample basis. It can contain mistakes, so confirm anything important against the original source. How we use AI
Who might be able to join this trial:
- People who have permanent or persistent atrial fibrillation (an irregular heart rhythm that does not go back to normal on its own)
- People who have moderate to severe heart failure symptoms (classified as NYHA Class II to IVa, meaning symptoms range from slight limitations during physical activity to discomfort even at rest)
- People who have been receiving standard, guideline-recommended heart failure medications for at least 3 months, AND who have a blood test result (called NT-proBNP) above a certain level — specifically: above 600 ng/L for people under 75 years old; above 900 ng/L for people aged 75 or older, or above 600 ng/L for people aged 75 or older who have been hospitalised for heart failure within the past year
Who may not be able to join:
- People who are currently in hospital needing intensive care or who have received intravenous heart-stimulating medications (inotropes) in the last 4 days
- People whose life expectancy is 1 year or less due to a non-heart-related illness, or who are expected to need a heart transplant within 1 year
- People who have had a heart attack within the last 4 weeks, or a procedure to open blocked heart arteries within the last 3 months
- People who are unable or unwilling to give their informed consent to participate
- People who have a significant heart valve problem that has not been treated, or who have an artificial tricuspid valve (a replaced valve on the right side of the heart)
- People who have certain specific types of heart muscle disease, including restrictive, hypertrophic, or irreversible cardiomyopathy
- People who have severe lung disease that requires ongoing oxygen therapy
- People who have a known or strongly suspected diagnosis of a specific type of high blood pressure in the lungs (WHO Class I pulmonary hypertension), including cases linked to connective tissue disease, heart defects present from birth, liver cirrhosis, HIV, certain blood disorders, parasitic infections, or certain medications
- People who are already enrolled in another clinical trial that could interfere with this study's goals
- People who already have a cardiac resynchronisation therapy (CRT) or biventricular pacemaker device already in place
- People who are pregnant
- People who meet the standard medical guidelines for needing a CRT device
- People who already have a pacemaker that is pacing the heart more than 20% of the time
- People with severe mobility limitations, such as those who are wheelchair-bound or who have serious neurological conditions that significantly restrict movement
Important: Always verify eligibility with the trial site directly before applying.
Based on publicly available eligibility criteria from ClinicalTrials.gov. Verify directly with the trial site before acting. This is not medical advice.
This is a simplified plain English summary of the eligibility criteria. Full criteria are set by the trial investigators and may include additional requirements not shown here. Never self-exclude from a trial based on this summary. Contact the trial site directly to confirm your eligibility.
This study is not part of the standard drug-approval phase pathway (for example an observational, device, behavioural, or registry study), so a phase success rate does not apply.
Contact this trial
Phone: 519-6633746
Contact details sourced from ClinicalTrials.gov. Verify directly with the trial site before attending.
GP referral letter
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Trial details
Status
Recruiting
Phase
Not Applicable
Sponsor
Habib Khan
Registry
ClinicalTrials.gov
Start date
25 April 2024
Est. completion
31 December 2028
Where this trial is recruiting
🇨🇦 Canada
Primary endpoints
Winratio
Can't join this trial?
Data last synced from ClinicalTrials.gov: 28 July 2026. Trial status can change. Always verify current status directly with the trial site before making any decision.
Trial recruitment status can change without notice between our nightly data updates. Always contact the trial site directly to confirm current recruitment status before making any decisions or travel arrangements.