Phase 1 Pancreatic Cancer Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• You are 19 years of age or older
• You have been diagnosed with a specific type of non-cancerous pancreatic cyst called a mucinous cystic neoplasm (MCN) that can be measured on a scan
• Your doctors are not planning surgery to remove the cyst, either because of the cyst's features, your health, or your own choice
• You are willing to use two forms of birth control throughout the study and for up to 3 months after treatment ends, if you are someone who could become pregnant or father a child (this does not apply if you are a woman aged 45 or older with no periods for 12 or more months, or if you have had your uterus and/or both ovaries surgically removed)
• Your kidneys are functioning well enough, based on a blood test result (confirm with trial site)
• You are willing and able to give your consent and follow the study's requirements

Who may not be able to join:

• You have been diagnosed with invasive pancreatic cancer or a more advanced pre-cancerous change in the cyst
• Your cyst or scan shows certain concerning features, such as a solid area, a widened pancreatic duct, yellowing of the skin (jaundice), or swollen lymph nodes
• You are currently using, or have used in the last 5 years, tamoxifen or similar medications that block estrogen (such as clomifene, raloxifene, fulvestrant, or anastrozole)
• You are currently using or planning to use hormone-based treatments such as estrogen, progesterone, androgens, hormone replacement therapy, or hormonal contraceptives like implants or injections (a hormonal IUD called levonorgestrel is allowed)
• You are pregnant or breastfeeding
• You have a known allergy or sensitivity to tamoxifen
• You have cataracts or eye problems that are already affecting your vision
• You currently take a blood-thinning medication called warfarin
• You have a history of blood clots in the legs or lungs, or another condition that puts you at higher risk of blood clots
• You have a history of stroke
• You have been diagnosed with abnormal growth of the womb lining, or have a history of uterine or endometrial cancer
• You have a bowel or stomach condition, or have had major stomach surgery, that could affect how your body absorbs the study medication, or you are unable to swallow pills
• You have a serious uncontrolled illness, such as an active infection needing IV antibiotics, heart failure, unstable chest pain, or an uncontrolled heart rhythm problem
• You have planned non-emergency surgery during the study period
• You have taken part in another clinical trial with an experimental treatment in the last 28 days
• The trial doctors believe, for any reason, that you would not be able to safely take part in or complete the study (confirm with trial site)

Important: Always verify eligibility with the trial site directly before applying.