Atrial Fibrillation Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People between 18 and 85 years of age
• People who are willing and able to give informed consent and attend all required follow-up visits
• People who have a confirmed diagnosis of atrial fibrillation (an irregular heart rhythm) within the past year, supported by a heart tracing or monitoring record
• People who are already scheduled for planned (non-emergency) open-heart surgery using a heart-lung bypass machine, for one or more of the following: mitral valve repair or replacement, aortic valve repair or replacement, repair of an enlarged section of the main artery from the heart, or coronary artery bypass surgery
• People whose heart pumping strength is at least 30%, as measured by a heart scan or procedure done within the past 60 days
• People with a life expectancy of at least 5 years

Who may not be able to join:

• People who have an implanted electronic heart device (such as a pacemaker, defibrillator, or a device attached to the left side of the heart)
• People who already have an artificial heart valve
• People whose only heart condition is atrial fibrillation, with no separate need for bypass or valve surgery
• People who have previously had a surgical Maze procedure (a specific heart rhythm operation)
• People who have had previous heart surgery
• People with certain other heart rhythm conditions, such as Wolff-Parkinson-White syndrome or related electrical pathway disorders
• People who need surgery for reasons other than bypass, heart valve, or a hole-in-the-heart repair
• People who have previously had a procedure involving instruments used inside the left chamber of the heart (such as a prior ablation)
• People with the most severe category of heart failure symptoms (confirm with trial site)
• People who have had a stroke or mini-stroke within the past 6 months, or at any time if lasting nerve or brain damage remains
• People who have had a heart attack with a specific type of ECG change (ST-elevation) within the past 6 weeks
• People who need emergency heart surgery
• People with a known narrowing of the neck arteries greater than 80%
• People with a currently active infection in the body
• People with severe blockage of arteries in the limbs that causes pain with very little physical activity
• People with kidney failure requiring dialysis, or serious liver failure
• People with a known addiction to alcohol or drugs
• People with a mental health condition or other reason that may prevent them from understanding what the study involves
• People who are pregnant or who plan to become pregnant within 12 months of the study treatment
• People who need heart-support devices or certain heart-strengthening medicines through a drip before surgery
• People who have previously received radiation treatment to the chest area
• People who are currently receiving chemotherapy
• People on long-term steroid tablets or injections (not including occasional use of steroid inhalers for breathing conditions)
• People with a known condition called hypertrophic obstructive cardiomyopathy (a thickening of the heart muscle that blocks blood flow)
• People with a known condition called cold agglutinin (where the immune system reacts to cold temperatures in a way that affects the blood)
• People with a history of abnormal bleeding or clotting problems
• People who are unable to take blood-thinning medications such as heparin, dabigatran, apixaban, or warfarin
• People who have had an organ or blood cell transplant, or who are currently being assessed for one
• People with a body mass index (a measure of body weight relative to height) above 40
• People who have taken part in another research study or used another experimental treatment or device within the past 30 days

Important: Always verify eligibility with the trial site directly before applying.